Beijing Institute of Technology, School of Chemical Engineering & the Environment, R&D Center for Pharmaceuticals, 5 South Zhongguancun Street, Beijing 100081, China.
Expert Opin Ther Pat. 2013 Sep;23(9):1157-79. doi: 10.1517/13543776.2013.800857. Epub 2013 May 16.
Benzimidazole is a heterocyclic aromatic system, which is part of some natural and many synthetic compounds. A large number of benzimidazoles and its derivatives are found to be biologically active against many diseases. Researchers around the world are paying greater attention to and showing increasing interests in this field.
Areas covered in this paper include a review of the synthesis, biological effects and mechanisms of benzimidazole derivatives in the past 2 years, based on literature and patents. The patent databases SciFinder and esp@cenet were used to locate patent applications that were published between 2010 to present. Information from articles published is also included. The current state and problems are also discussed.
Benzimidazole derivatives possess a broad spectrum of biological activities, whose scopes of treatment ranging from ordinary antimicrobial activities to world's most deadly diseases. However, challenges such as drug resistance, relatively little knowledge of structure of receptors and rare convenient methods for synthesis of benzimidazoles still exist.
苯并咪唑是一种杂环芳族体系，它是一些天然和许多合成化合物的一部分。大量的苯并咪唑及其衍生物被发现对许多疾病具有生物活性。世界各地的研究人员越来越关注这一领域，并表现出越来越大的兴趣。
本文综述了过去 2 年中苯并咪唑衍生物的合成、生物效应和作用机制，参考文献和专利。专利数据库 SciFinder 和 esp@cenet 用于定位 2010 年至今公布的专利申请。还包括从已发表文章中获取的信息。目前的状况和问题也进行了讨论。
苯并咪唑衍生物具有广泛的生物活性，其治疗范围从普通的抗菌活性到世界上最致命的疾病。然而，仍然存在一些挑战，如耐药性、对受体结构的了解相对较少以及苯并咪唑合成的便捷方法罕见等。
