Frandsen Christine J, Brammer Karla S, Jin Sungho
Materials Science and Engineering Program, University of California, San Diego, La Jolla, CA 92093-0411, USA.
Int J Biomater. 2013;2013:513680. doi: 10.1155/2013/513680. Epub 2013 Apr 28.
The complex mechanisms of the bone cell-surface interactions are yet to be completely understood, and researchers continue to strive to uncover the fully optimized implant material for perfect osseointegration. A particularly fascinating area of research involves the study of nanostructured surfaces, which are believed to enhance osteogenic behavior, possibly due to the mimicry of components of the extracellular matrix of bone. There is a growing body of data that emphasizes the promise of the titanium oxide (TiO2) nanotube architecture as an advanced orthopedic implant material. The review herein highlights findings regarding TiO2 nanotube surfaces for bone regeneration and the osteogenic effects of minute changes to the surface such as tube size and surface chemistry.
骨细胞与表面相互作用的复杂机制尚未完全被理解，研究人员仍在努力寻找能实现完美骨整合的完全优化的植入材料。一个特别引人入胜的研究领域涉及对纳米结构表面的研究，据信这种表面可增强成骨行为，这可能是由于其模仿了骨细胞外基质的成分。越来越多的数据强调了二氧化钛（TiO2）纳米管结构作为一种先进的骨科植入材料的前景。本文综述重点介绍了关于TiO2纳米管表面促进骨再生的研究结果，以及诸如管径和表面化学性质等表面微小变化所产生的成骨作用。
