a Institute of Health and Wellbeing, Public Health , University of Glasgow , Glasgow , UK.
Nutr Cancer. 2012 Aug;64(6):790-7. doi: 10.1080/01635581.2012.690063. Epub 2012 Jun 14.
Tea may be a potentially modifiable and highly prevalent risk factor for the most common cancer in men, prostate cancer. However, associations between black tea consumption and prostate cancer in epidemiological studies have been inconsistent, limited to a small number of studies with small numbers of cases and short follow-up periods and without grade-specific information. We conducted a prospective cohort study of 6,016 men who were enrolled in the Collaborative Cohort Study between 1970 and 1973 and followed up to December 31, 2007. We used Cox proportional hazards models to investigate the association between tea consumption and overall as well as grade-specific risk of prostate cancer incidence. Three hundred and eighteen men developed prostate cancer in up to 37 years of follow-up. We found a positive association between consumption of tea and overall risk of prostate cancer incidence (P = 0.02). The association was greatest among men who drank ≥ 7 cups of tea per day (HR: 1.50, 95% CI: 1.06 to 2.12), compared with the baseline of 0-3 cups/day. However, we did not find any significant association between tea intake and low- (Gleason <7) or high-grade (Gleason 8-10) prostate cancer incidence. Men with higher intake of tea are at greater risk of developing prostate cancer, but there is no association with more aggressive disease. Further research is needed to determine the underlying biological mechanisms for the association.
茶可能是男性最常见的癌症——前列腺癌的一个潜在可改变的、高度流行的风险因素。然而，在流行病学研究中，红茶的摄入与前列腺癌之间的关联并不一致，这些研究仅限于少数几项研究，这些研究的病例数量较少，随访时间较短，且没有特定分级的信息。我们对 6016 名男性进行了一项前瞻性队列研究，这些男性于 1970 年至 1973 年期间参加了合作队列研究，并随访至 2007 年 12 月 31 日。我们使用 Cox 比例风险模型来研究茶的摄入与前列腺癌总体及特定分级发病率的关系。在长达 37 年的随访中，有 318 名男性患上了前列腺癌。我们发现茶的摄入与前列腺癌总体发病率的风险呈正相关（P=0.02）。与每天饮用 0-3 杯茶的基线相比，每天饮用≥7 杯茶的男性关联最大（HR：1.50，95%CI：1.06 至 2.12）。然而，我们没有发现茶的摄入量与低分级（Gleason<7）或高分级（Gleason 8-10）前列腺癌发病率之间存在任何显著关联。摄入更多茶的男性患前列腺癌的风险更高，但与侵袭性更强的疾病无关。需要进一步的研究来确定这种关联的潜在生物学机制。
