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自闭症,维生素 D 能治疗核心症状吗?

Autism, will vitamin D treat core symptoms?

机构信息

Vitamin D Council, 697 Higuera Street, Suite H, San Luis Obispo 93401, USA.

出版信息

Med Hypotheses. 2013 Aug;81(2):195-8. doi: 10.1016/j.mehy.2013.05.004. Epub 2013 May 29.

Abstract

No medication exists to treat the core symptoms of autism. However, some children spontaneously improve and have optimal outcomes. Parents of autistic children who have access to swimming pool have reported summertime improvement in symptoms to me. A Japanese case report found the same summer times improvements. If the cause of that summertime improvement could be identified, it may lead to effective treatment. Vitamin D is highly seasonal with a summertime surfeit and a wintertime deficit. The hypotheses that the increased prevalence in the diagnosis of autism is due to better detection imply that parents, teachers and physicians of the 1950s, 60s, and 70s missed this non subtle diagnosis, an unlikely scenario. Recent research indicates that autism often first present itself during the second and third year of life. This is a time when most toddlers have no known sources of vitamin D. Vitamin D has remarkable antioxidant, anti-inflammatory, and anti-autoimmune properties. In vitro, in vivo, and animal experiments provide compelling data for vitamin D's role brain proliferation, differentiation, neurotrophism, neuroprotection, neurotransmission, and neuroplasticity. It also upregulates glutathione, upregulates a suit of genes involved in DNA repair and raises the seizure threshold. Adequate, perhaps pharmacological, doses of vitamin D may have a treatment effect in the core symptoms of autism.

摘要

目前尚无药物可治疗自闭症的核心症状。然而,一些儿童会自发地改善并取得最佳效果。我曾收到过一些自闭症儿童的家长报告,称夏季时他们的症状有所改善。一份日本的病例报告也发现了同样的夏季改善现象。如果能确定导致夏季改善的原因,也许就能找到有效的治疗方法。维生素 D 具有很强的季节性,夏季过剩而冬季不足。假设自闭症诊断率的增加是由于检测水平提高所致,这意味着 50 年代、60 年代和 70 年代的父母、教师和医生错过了这种非明显的诊断,这种情况不太可能发生。最近的研究表明,自闭症通常在儿童 2 到 3 岁时首次出现。此时,大多数幼儿体内没有已知的维生素 D 来源。维生素 D 具有显著的抗氧化、抗炎和抗自身免疫特性。体外、体内和动物实验都为维生素 D 在大脑增殖、分化、神经营养、神经保护、神经传递和神经可塑性方面的作用提供了令人信服的数据。它还能上调谷胱甘肽,上调一套参与 DNA 修复的基因,并提高癫痫发作阈值。适当的、或许是药理学剂量的维生素 D 可能对自闭症的核心症状有治疗作用。

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