Xiao Nan, Humphrey Jay D, Figueroa C Alberto
Department of Bioengineering, Stanford University, Stanford, CA 94305 USA ; Department of Biomedical Engineering, King's College London, London SE1 7EH, UK.
J Comput Phys. 2013 Jul 1;244:22-40. doi: 10.1016/j.jcp.2012.09.016.
In this article, we present a computational multi-scale model of fully three-dimensional and unsteady hemodynamics within the primary large arteries in the human. Computed tomography image data from two different patients were used to reconstruct a nearly complete network of the major arteries from head to foot. A linearized coupled-momentum method for fluid-structure-interaction was used to describe vessel wall deformability and a multi-domain method for outflow boundary condition specification was used to account for the distal circulation. We demonstrated that physiologically realistic results can be obtained from the model by comparing simulated quantities such as regional blood flow, pressure and flow waveforms, and pulse wave velocities to known values in the literature. We also simulated the impact of age-related arterial stiffening on wave propagation phenomena by progressively increasing the stiffness of the central arteries and found that the predicted effects on pressure amplification and pulse wave velocity are in agreement with findings in the clinical literature. This work demonstrates the feasibility of three-dimensional techniques for simulating hemodynamics in a full-body compliant arterial network.
在本文中，我们展示了一个关于人体主要大动脉内全三维非稳态血流动力学的计算多尺度模型。使用来自两名不同患者的计算机断层扫描图像数据重建了一个从头部到脚部的几乎完整的主要动脉网络。采用用于流固相互作用的线性化耦合动量方法来描述血管壁的可变形性，并使用用于流出边界条件指定的多域方法来考虑远端循环。通过将模拟量（如局部血流、压力和血流波形以及脉搏波速度）与文献中的已知值进行比较，我们证明了该模型可以获得符合生理实际的结果。我们还通过逐步增加中心动脉的硬度来模拟与年龄相关的动脉僵硬对波传播现象的影响，发现对压力放大和脉搏波速度的预测影响与临床文献中的发现一致。这项工作证明了在全身顺应性动脉网络中模拟血流动力学的三维技术的可行性。
