Cancer Molecular Pathology Research Center, Department of Hematopathology and Blood Banking, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Phytother Res. 2014 Apr;28(4):539-43. doi: 10.1002/ptr.5021. Epub 2013 Jun 3.
Saffron showed some effects on blood coagulation and platelet aggregation in in vitro and in vivo studies. In a clinical trial with a limited number volunteers, saffron tablets influenced on bleeding time. In this study, the effect of saffron on plasma level of fibrinogen, factor VII (as coagulant agent), C and S protein (as anti-coagulant agent), PT and PTT in a larger sample size was evaluated. The study was a double-blind, placebo-controlled study consisting of 1 week treatment with 200 mg and 400 mg saffron tablets. Sixty healthy volunteers (age range 20-50 years) were selected for the study. The volunteers were divided into three groups of 20 each. Group 1 received placebo; Groups 2 and 3 received 200 mg and 400 mg saffron tablets, respectively, for 7 days (1 tablet per day). Before and after 7 days treatment and also 1 month after that, blood samples were taken. The plasma levels of fibrinogen, factor VII, C and S protein, PT and PTT were evaluated. Statistical analysis showed no difference between groups for any of evaluated factors. This study rejected any effect of saffron with dose of 200 and 400 mg for 1 week on coagulant and anticoagulant system.
藏红花在体外和体内研究中显示出对凝血和血小板聚集的一些影响。在一项志愿者人数有限的临床试验中，藏红花片剂影响了出血时间。在这项研究中，评估了更大样本量的藏红花对纤维蛋白原、因子 VII（作为凝血剂）、C 和 S 蛋白（作为抗凝剂）、PT 和 PTT 血浆水平的影响。该研究是一项双盲、安慰剂对照研究，包括 1 周的 200mg 和 400mg 藏红花片剂治疗。选择了 60 名健康志愿者（年龄在 20-50 岁之间）进行研究。志愿者分为三组，每组 20 人。第 1 组接受安慰剂；第 2 组和第 3 组分别接受 200mg 和 400mg 藏红花片剂，每天 1 片，持续 7 天。在 7 天治疗前后以及 1 个月后，采集血样。评估了纤维蛋白原、因子 VII、C 和 S 蛋白、PT 和 PTT 的血浆水平。统计分析显示，在任何评估因素方面，各组之间均无差异。这项研究否定了藏红花剂量为 200mg 和 400mg 持续 1 周对凝血和抗凝系统的任何影响。
