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Toll样受体3（TLR3）配体对肿瘤微环境的免疫调节作用

Immunomodulation of the tumor microenvironment by Toll-like receptor-3 (TLR3) ligands.

作者信息

Chew Valerie, Abastado Jean-Pierre

机构信息

Singapore Immunology Network (SIgN); Agency for Science Technology and Research (ASTAR); 8A Biomedical Grove; Immunos; Biopolis, Singapore.

出版信息

Oncoimmunology. 2013 Apr 1;2(4):e23493. doi: 10.4161/onci.23493.

DOI:10.4161/onci.23493
PMID:23734310
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3654580/
Abstract

In hepatocellular carcinoma (HCC) patients, the intratumoral expression of Toll-like receptor-3 (TLR3) correlates with prolonged survival. We demonstrated that TLR3 ligands can operate through three independent mechanisms: by directly killing TLR3-expressing cancer cells, by inducing T- and natural killer (NK)-cell infiltration and by activating TLR3-expressing NK cells.

摘要

在肝细胞癌（HCC）患者中，Toll样受体3（TLR3）的肿瘤内表达与生存期延长相关。我们证明，TLR3配体可通过三种独立机制发挥作用：直接杀死表达TLR3的癌细胞、诱导T细胞和自然杀伤（NK）细胞浸润以及激活表达TLR3的NK细胞。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d625/3654580/4731c1d6f723/onci-2-e23493-g1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d625/3654580/4731c1d6f723/onci-2-e23493-g1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d625/3654580/4731c1d6f723/onci-2-e23493-g1.jpg

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本文引用的文献

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2
Trial Watch: Experimental Toll-like receptor agonists for cancer therapy.试验观察：用于癌症治疗的实验性 Toll 样受体激动剂。
Oncoimmunology. 2012 Aug 1;1(5):699-716. doi: 10.4161/onci.20696.
3
NF-κB hyperactivation in tumor tissues allows tumor-selective reprogramming of the chemokine microenvironment to enhance the recruitment of cytolytic T effector cells.
Toll样受体3（TLR3）表达是一种潜在的预后生物标志物，并塑造了食管鳞状细胞癌的免疫活性肿瘤微环境。
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The correlation between tumor-associated macrophage infiltration and progression in cervical carcinoma.肿瘤相关巨噬细胞浸润与宫颈癌进展的相关性。
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