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蜜蜡蜂胶的生物活性部分可减少炎症过程中的中性粒细胞迁移：涉及一氧化氮途径。

Bioactive Fraction of Geopropolis from Melipona scutellaris Decreases Neutrophils Migration in the Inflammatory Process: Involvement of Nitric Oxide Pathway.

机构信息

Department of Physiological Sciences, School of Dentistry of Piracicaba, University of Campinas, 901 Limeira Ave., 13414 903 Piracicaba, SP, Brazil.

出版信息

Evid Based Complement Alternat Med. 2013;2013:907041. doi: 10.1155/2013/907041. Epub 2013 Apr 30.

DOI:10.1155/2013/907041
PMID:23737853
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3657425/
Abstract

The aim of this study was to evaluate the activity of the ethanolic extract of geopropolis (EEGP) from Melipona scutellaris and its fractions on the modulation of neutrophil migration in the inflammatory process, and the participation of nitric oxide (NO) pathway, as well as to check the chemical profile of the bioactive fraction. EEGP and its aqueous fraction decreased neutrophil migration in the peritoneal cavity and also the interaction of leukocytes (rolling and adhesion) with endothelial cells. The levels of chemokines CXCL1/KC and CXCL2/MIP-2 were not altered after treatment with EEGP and the aqueous fraction. It was found that the injection of NO pathway antagonists abolished the EEGP and the aqueous fraction inhibitory activity on the neutrophil migration. The expression of intercellular adhesion molecule type 1 (ICAM-1) was reduced, and nitrite levels increased after treatment with EEGP and aqueous fraction. In the carrageenan-induced paw edema model, EEGP and the aqueous fraction showed antiedema activity. No pattern of flavonoid and phenolic acid commonly found in propolis samples of Apis mellifera could be detected in the aqueous fraction samples. These data indicate that the aqueous fraction found has promising bioactive substances with anti-inflammatory activity.

摘要

本研究旨在评估 Melipona scutellaris 地理蜂胶（EEGP）的乙醇提取物及其馏分对炎症过程中中性粒细胞迁移的调节作用，以及一氧化氮（NO）途径的参与，并检查生物活性馏分的化学特征。EEGP 和其水相部分降低了腹腔内中性粒细胞的迁移以及白细胞（滚动和黏附）与内皮细胞的相互作用。用 EEGP 和水相部分处理后，趋化因子 CXCL1/KC 和 CXCL2/MIP-2 的水平没有改变。结果发现，注射 NO 途径拮抗剂可消除 EEGP 和水相部分对中性粒细胞迁移的抑制活性。细胞间黏附分子 1（ICAM-1）的表达减少，经 EEGP 和水相部分处理后亚硝酸盐水平升高。在角叉菜胶诱导的爪肿胀模型中，EEGP 和水相部分表现出抗水肿活性。在水相部分样品中未检测到通常存在于 Apis mellifera 蜂胶样品中的类黄酮和酚酸模式。这些数据表明，所发现的水相部分具有有前景的抗炎活性的生物活性物质。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f9f2/3657425/b30931f65513/ECAM2013-907041.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f9f2/3657425/7d2ae94d1777/ECAM2013-907041.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f9f2/3657425/5e29c0415e85/ECAM2013-907041.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f9f2/3657425/8f85bff7b8ee/ECAM2013-907041.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f9f2/3657425/e33df7578fca/ECAM2013-907041.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f9f2/3657425/04e946761e66/ECAM2013-907041.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f9f2/3657425/b30931f65513/ECAM2013-907041.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f9f2/3657425/7d2ae94d1777/ECAM2013-907041.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f9f2/3657425/5e29c0415e85/ECAM2013-907041.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f9f2/3657425/8f85bff7b8ee/ECAM2013-907041.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f9f2/3657425/e33df7578fca/ECAM2013-907041.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f9f2/3657425/04e946761e66/ECAM2013-907041.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f9f2/3657425/b30931f65513/ECAM2013-907041.006.jpg

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