Muttini Aurelio, Salini Vincenzo, Valbonetti Luca, Abate Michele
Department of Comparative Biomedical Sciences, University of Teramo, Italy ; Stem TeCh group, Chieti Scalo, Italy.
Muscles Ligaments Tendons J. 2012 Oct 16;2(3):187-92. Print 2012 Jul.
The ideal strategy for tendon healing has not been identified to date. Recently, the use of stem cells based therapy has been proposed, due to their ability to proliferate and to differentiate towards specific connective tissues lineages. Embryonic stem cells should be considered the ideal cell source for regenerative therapies, but ethical factors limit their use in humans. Mesenchymal stem cells are more easily available and can be obtained by different sources. Amnion derived stem cells can differentiate towards all three germ layers, and can be used for allogeneic transplantation and stored thanks to cryopreservation. In veterinary medicine, stem cells have been used with encouraging results for the treatment of the Superficial Digital Flexor tendinopathy in the horses. Considering that Superficial Digital Flexor tendinopathy is similar for pathogenesis and histopathology to Achilles tendinopathy in man, this experience can provide supportive data to encourage the use of regenerative therapy in humans.
迄今为止，尚未确定肌腱愈合的理想策略。最近，由于干细胞具有增殖能力并能向特定结缔组织谱系分化，基于干细胞的疗法被提了出来。胚胎干细胞应被视为再生疗法的理想细胞来源，但伦理因素限制了它们在人类中的应用。间充质干细胞更容易获得，可以从不同来源获取。羊膜来源的干细胞可以向所有三个胚层分化，并且由于可以冷冻保存，可用于同种异体移植。在兽医学中，干细胞已被用于治疗马的指浅屈肌腱病，取得了令人鼓舞的结果。鉴于指浅屈肌腱病在发病机制和组织病理学上与人类的跟腱病相似，这一经验可为鼓励在人类中使用再生疗法提供支持性数据。
