自然、教养与 HIV：供体细胞对病毒生理学的影响。
Nature, nurture and HIV: The effect of producer cell on viral physiology.
机构信息
Department of Microbiology, Immunology and Tropical Medicine, School of Medicine and Health Sciences, George Washington University, 2300 I Street NW, Ross Hall, Washington, DC 20037, USA.
出版信息
Virology. 2013 Sep 1;443(2):208-13. doi: 10.1016/j.virol.2013.05.023. Epub 2013 Jun 5.
Abstract
Macrophages and CD4-positive T lymphocytes are the major targets and producers of HIV-1. While the molecular details underlying HIV replication in macrophages and T cells become better understood, it remains unclear whether viruses produced by these target cells differ in their biological properties. Recent reports suggest that HIV virions incorporate a large number of producer cell proteins and lipids which have an effect on subsequent viral replication in newly infected cells. The identity and abundance of these incorporated factors varies between different types of producer cells, suggesting that they may influence the replication capacity and pathogenic activity of the virions produced by T cells and macrophages.
摘要
巨噬细胞和 CD4 阳性 T 淋巴细胞是 HIV-1 的主要靶细胞和产生细胞。虽然人们对巨噬细胞和 T 细胞中 HIV 复制的分子细节有了更好的了解，但仍不清楚这些靶细胞产生的病毒在生物学特性上是否存在差异。最近的报告表明，HIV 病毒粒子中包含大量产生细胞的蛋白质和脂质，这些物质会影响新感染细胞中随后的病毒复制。这些整合因子的种类和丰度在不同类型的产生细胞之间有所不同，这表明它们可能影响 T 细胞和巨噬细胞产生的病毒粒子的复制能力和致病活性。
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