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从褐藻条斑紫菜中分离岩藻黄质和高度不饱和单半乳糖基二酰基甘油及其体外抗肿瘤活性研究。

Isolation of fucoxanthin and highly unsaturated monogalactosyldiacylglycerol from brown alga Fucus evanescens C Agardh and in vitro investigation of their antitumor activity.

机构信息

G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch, Russian Academy of Sciences, Prospect 100-letya Vladivostoka, 159, Vladivostok, 690022, Russia.

出版信息

Mar Biotechnol (NY). 2013 Oct;15(5):606-12. doi: 10.1007/s10126-013-9507-2. Epub 2013 Jun 11.

DOI:10.1007/s10126-013-9507-2
PMID:23748883
Abstract

Fucoxanthin (FX) and highly unsaturated monogalactosyldiacylglycerol (MGDG) were isolated from the ethanol extract of brown alga Fucus evanescens. Their structures were identified by nuclear magnetic resonance, complemented by electrospray ionization mass spectrometry (ESIMS). MGDG was identified as 1-O-(5Z,8Z,11Z,14Z,17Z-eicosapentanoyl)-2-O-(6Z,9Z,12Z,15Z-octadecatetraenoyl)-3-O-β-D-galactopiranosyl-sn-glycerol. Antitumor activity of these compounds was tested on human melanoma (SK-MEL-28) cells. MGDG and FX inhibited the growth of human melanoma cells in a dose-dependent manner. IC50 values for growth inhibition were 104 and 114 μM, correspondently.

摘要

岩藻黄质 (FX) 和高度不饱和单半乳糖基二酰基甘油 (MGDG) 从褐藻马尾藻的乙醇提取物中分离得到。它们的结构通过核磁共振鉴定，并辅以电喷雾电离质谱 (ESIMS) 进行补充。MGDG 被鉴定为 1-O-(5Z,8Z,11Z,14Z,17Z-eicosapentanoyl)-2-O-(6Z,9Z,12Z,15Z-octadecatetraenoyl)-3-O-β-D-galactopyranosyl-sn-glycerol。对这些化合物的抗肿瘤活性进行了测试，结果显示其对人黑色素瘤 (SK-MEL-28) 细胞具有抑制作用。MGDG 和 FX 呈剂量依赖性抑制人黑色素瘤细胞的生长，其生长抑制的 IC50 值分别为 104 和 114 μM。

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