National Center for Drug Screening and State Key Laboratory of Natural Medicines, China Pharmaceutical University, Jiangsu Province, China.
J Diabetes Res. 2013;2013:170532. doi: 10.1155/2013/170532. Epub 2013 May 16.
Obesity is a major risk factor for insulin resistance and type 2 diabetes. Adipose tissue is now considered to be an active endocrine organ that secretes various adipokines such as adiponectin, leptin, resistin, tumour necrosis factor-α, and interleukin-6. Recent studies have shown that these factors might provide a molecular link between increased adiposity and impaired insulin sensitivity. Since hepatic insulin resistance plays the key role in the whole body insulin resistance, clarification of the regulatory processes about hepatic insulin resistance by adipokines in rodents and human would seem essential in order to understand the mechanism of type 2 diabetes and for developing novel therapeutic strategies to treat it.
肥胖是胰岛素抵抗和 2 型糖尿病的一个主要危险因素。脂肪组织现在被认为是一种活跃的内分泌器官，它分泌各种脂肪因子，如脂联素、瘦素、抵抗素、肿瘤坏死因子-α 和白细胞介素-6。最近的研究表明，这些因素可能为肥胖增加和胰岛素敏感性受损之间提供了一个分子联系。由于肝胰岛素抵抗在全身胰岛素抵抗中起着关键作用，因此了解脂肪因子在啮齿动物和人类中对肝胰岛素抵抗的调节过程，对于理解 2 型糖尿病的发病机制和开发治疗该病的新策略似乎是至关重要的。
