可伸缩弹性支架中的 3D 结构模式指导工程组织架构。
3D structural patterns in scalable, elastomeric scaffolds guide engineered tissue architecture.
机构信息
Harvard-MIT Division of Health Sciences and Technology, David H. Koch Institute for Integrative Cancer Research, Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
出版信息
Adv Mater. 2013 Aug 27;25(32):4459-65. doi: 10.1002/adma.201301016. Epub 2013 Jun 14.
Abstract
Microfabricated elastomeric scaffolds with 3D structural patterns are created by semiautomated layer-by-layer assembly of planar polymer sheets with through-pores. The mesoscale interconnected pore architectures governed by the relative alignment of layers are shown to direct cell and muscle-like fiber orientation in both skeletal and cardiac muscle, enabling scale up of tissue constructs towards clinically relevant dimensions.
摘要
通过半自动化逐层组装带有贯穿孔的平面聚合物片，制造出具有 3D 结构图案的微制造弹性支架。通过层的相对对准来控制的介观互连孔结构被证明可以指导骨骼和心肌中的细胞和肌原纤维的取向，从而使组织构建物能够朝着临床相关的尺寸进行放大。
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