School of Chemistry, University of Glasgow, University Avenue, Glasgow G12 8QQ, UK. Web: http://www.croninlab.com.
Beilstein J Org Chem. 2013 May 16;9:951-9. doi: 10.3762/bjoc.9.109. Print 2013.
We present a study in which the versatility of 3D-printing is combined with the processing advantages of flow chemistry for the synthesis of organic compounds. Robust and inexpensive 3D-printed reactionware devices are easily connected using standard fittings resulting in complex, custom-made flow systems, including multiple reactors in a series with in-line, real-time analysis using an ATR-IR flow cell. As a proof of concept, we utilized two types of organic reactions, imine syntheses and imine reductions, to show how different reactor configurations and substrates give different products.
我们提出了一项研究，该研究将 3D 打印的多功能性与流动化学的处理优势相结合，用于有机化合物的合成。坚固且廉价的 3D 打印反应设备可以使用标准配件轻松连接，从而形成复杂的定制流动系统，包括使用 ATR-IR 流通池进行在线实时分析的串联多个反应器。作为概念验证，我们利用两种类型的有机反应，亚胺合成和亚胺还原，展示了不同的反应器配置和底物如何产生不同的产物。
