Department of Cardiology, Xijing Hospital, The Fourth Military Medical University, Xi'an, China 710032.
Nanoscale. 2013 Aug 7;5(15):6857-66. doi: 10.1039/c3nr01573d.
Herein we report the design and synthesis of multifunctional VEGF-loaded IR800-conjugated graphene oxide (GO-IR800-VEGF) for multi-modality imaging-monitored therapeutic angiogenesis of ischemic muscle. The as-prepared GO-IR800-VEGF positively targets VEGF receptors, maintains an elevated level of VEGF in ischemic tissues for a prolonged time, and finally leads to remarkable therapeutic angiogenesis of ischemic muscle. Although more efforts are required to further understand the in vivo behaviors and the long-term toxicology of GO, our work demonstrates the success of using GO for efficient VEGF delivery in vivo by intravenous administration and suggests the great promise of using graphene oxide in theranostic applications for treating ischemic disease.
在这里，我们报告了多功能载 VEGF 的 IR800 偶联氧化石墨烯（GO-IR800-VEGF）的设计和合成，用于缺血性肌肉的多模式成像监测治疗性血管生成。所制备的 GO-IR800-VEGF 可特异性靶向 VEGF 受体，在缺血组织中长时间维持高水平的 VEGF，最终导致缺血肌肉的显著治疗性血管生成。尽管还需要进一步努力来更深入地了解 GO 的体内行为和长期毒理学，但我们的工作证明了通过静脉注射使用 GO 进行体内有效 VEGF 传递的成功，并表明了氧化石墨烯在治疗缺血性疾病的治疗应用中的巨大应用前景。
