Fu Wai Hospital, National Center for Cardiovascular Disease, Chinese Academy of Medical Sciences and Peking Union Medical College, Division of Cardiology, State Key Laboratory of Cardiovascular Disease, Beijing/China.
Clinics (Sao Paulo). 2013 Jun;68(6):732-7. doi: 10.6061/clinics/2013(06)02.
An elevated red cell distribution width has been recognized as a predictor of various cardiovascular diseases. Slow coronary flow syndrome is an important angiographic clinical entity with an unknown etiology. This study aimed to examine the relationship between red cell distribution width and the presence of slow coronary flow syndrome.
In total, 185 patients with slow coronary flow syndrome and 183 age- and gender-matched subjects with normal coronary flow (controls) were prospectively enrolled in this study. Red cell distribution width and C-reactive protein were measured upon admission, and the results were compared between the patients with slow coronary flow syndrome and normal controls.
Red cell distribution width levels were significantly higher in the patients with slow coronary flow syndrome than the normal controls. Moreover, the data showed that the plasma C-reactive protein levels were also higher in the patients with slow coronary flow syndrome than in the normal controls. In addition, a multivariate analysis indicated that C-reactive protein and red cell distribution width were the independent variables most strongly associated with slow coronary flow syndrome. Finally, the red cell distribution width was positively correlated with C-reactive protein and mean thrombosis in the myocardial infarction frame counts of the patients with slow coronary flow syndrome.
The data demonstrated that red cell distribution width levels are significantly higher and strongly positively correlated with both C-reactive protein and thrombosis in the myocardial infarction frame counts of patients with slow coronary flow syndrome. These findings suggest that red cell distribution width may be a useful marker for patients with slow coronary flow syndrome.
红细胞分布宽度升高已被认为是多种心血管疾病的预测指标。慢血流综合征是一种重要的血管造影临床实体，其病因不明。本研究旨在探讨红细胞分布宽度与慢血流综合征之间的关系。
本研究前瞻性纳入了 185 例慢血流综合征患者和 183 例年龄和性别匹配的正常冠状动脉血流（对照组）患者。入院时测量红细胞分布宽度和 C 反应蛋白，并比较慢血流综合征患者与正常对照组之间的结果。
慢血流综合征患者的红细胞分布宽度水平明显高于正常对照组。此外，数据显示，慢血流综合征患者的血浆 C 反应蛋白水平也高于正常对照组。此外，多变量分析表明，C 反应蛋白和红细胞分布宽度是与慢血流综合征最密切相关的独立变量。最后，红细胞分布宽度与慢血流综合征患者的 C 反应蛋白和心肌梗死帧数的平均血栓呈正相关。
数据表明，慢血流综合征患者的红细胞分布宽度水平明显升高，并与 C 反应蛋白和心肌梗死帧数的血栓形成呈强烈正相关。这些发现表明，红细胞分布宽度可能是慢血流综合征患者的一个有用标志物。
