Department of Obstetrics and Gynecology, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
Medicine (Baltimore). 2024 Oct 11;103(41):e39957. doi: 10.1097/MD.0000000000039957.
Cervical cancer is the fourth most common cancer in women worldwide. The vast majority of cervical cancers are associated with human papillomavirus (HPV) infection, but a small proportion of cervical cancers occur independently of HPV infection, with different subtypes having varying rates of occurrence. Despite the presence of false negatives in current testing, improving the accuracy of detection is crucial for studying the pathogenesis of HPV-negative cervical cancer and improving the prognosis of these patients. Existing research suggests that HPV-negative cervical cancer has a different pathogenesis from HPV-positive cervical cancer, although the exact mechanism is not yet clear. It is currently believed to be associated with the immune microenvironment, certain tumor gene mutations, and some long noncoding RNAs. This article provides an overview of the latest research progress on HPV-negative cervical cancer, including possible reasons, pathogenesis, pathological features, and clinical characteristics, aiming to provide new insights for diagnosis, treatment, and prognosis improvement.
宫颈癌是全球女性中第四常见的癌症。绝大多数宫颈癌与人类乳头瘤病毒（HPV）感染有关，但一小部分宫颈癌独立于 HPV 感染发生，不同亚型的发生率也不同。尽管目前的检测存在假阴性，但提高检测的准确性对于研究 HPV 阴性宫颈癌的发病机制和改善这些患者的预后至关重要。现有研究表明，HPV 阴性宫颈癌的发病机制与 HPV 阳性宫颈癌不同，尽管确切机制尚不清楚。目前认为它与免疫微环境、某些肿瘤基因突变和一些长链非编码 RNA 有关。本文综述了 HPV 阴性宫颈癌的最新研究进展，包括可能的原因、发病机制、病理特征和临床特征，旨在为诊断、治疗和预后改善提供新的思路。
