Harvard NeuroDiscovery Center, Harvard Medical School and Brigham & Women's Hospital, 65 Landsdowne Street, Cambridge, MA 02139, USA.
Angew Chem Int Ed Engl. 2013 Jul 22;52(30):7860-4. doi: 10.1002/anie.201303483. Epub 2013 Jun 19.
Visible advance: A mild, one-pot Stadler-Ziegler process for C-S bond formation has been developed. The method employs the photoredox catalyst [Ru(bpy)3Cl2]⋅6 H2O irradiated with visible light. A variety of aryl-alkyl and diaryl sulfides were prepared from readily available arylamines and aryl/alkylthiols in good yields. The use of a photo microreactor led to a significant improvement with respect to safety and efficiency.
开发了一种温和、一锅法的 Stadler-Ziegler 反应用于 C-S 键形成。该方法采用可见光照射光氧化还原催化剂 [Ru(bpy)3Cl2]⋅6H2O。各种芳基-烷基和二芳基硫醚可由易得的芳胺和芳基/烷基硫醇以良好的收率制备得到。使用光微反应器在安全性和效率方面有显著提高。
