Department of Pathobiology, Faculty of Veterinary Medicine, Utrecht University, Yalelaan 1, P.O. Box 80.158, 3508TD Utrecht, The Netherlands.
Comp Immunol Microbiol Infect Dis. 2013 Sep;36(5):449-64. doi: 10.1016/j.cimid.2013.05.001. Epub 2013 Jun 18.
Clostridium perfringens is one of the major causes of intestinal disease in humans and animals. Its pathogenicity is contributed to by the production of a variety of toxins. In addition, predisposing environmental factors are important for the induction of C. perfringens-associated enteritis as shown by infection models. Environmental contamination, gastric and intestinal pH, intestinal microflora, nutrition, concurrent infections, and medical interventions may influence the intestinal colonization, growth, and toxin production by C. perfringens. Prevention of C. perfringens-associated enteritis may be mediated by the use of feed additives like probiotics, prebiotics, organic acids, essential oils, bacteriophages, lysozymes, bacteriocins, and antimicrobial peptides. Here we summarize and discuss published data on the influence of different environmental predisposing factors and preventive measures. Further research should focus on feed composition and feed additives in order to prevent C. perfringens-associated enteritis.
产气荚膜梭菌是人类和动物肠道疾病的主要原因之一。其致病性与其产生的多种毒素有关。此外，如感染模型所示，诱发环境因素对于诱导产气荚膜梭菌相关性肠炎也很重要。环境污染、胃和肠道 pH 值、肠道微生物群、营养、合并感染和医疗干预可能会影响产气荚膜梭菌的肠道定植、生长和毒素产生。通过使用益生菌、益生元、有机酸、精油、噬菌体、溶菌酶、细菌素和抗菌肽等饲料添加剂，可能有助于预防产气荚膜梭菌相关性肠炎。在这里，我们总结和讨论了已发表的关于不同环境诱发因素和预防措施影响的资料。进一步的研究应集中在饲料成分和饲料添加剂上，以预防产气荚膜梭菌相关性肠炎。
