Pediatric Clinic, Malmö, Skåne University Hospital, Lund University, Lund, Sweden ; Departments of Respiratory Medicine and Allergology, Skåne University Hospital, Lund University, Lund, Sweden.
Pediatric Clinic, Malmö, Skåne University Hospital, Lund University, Lund, Sweden.
Clin Transl Allergy. 2013 Jun 22;3:19. doi: 10.1186/2045-7022-3-19. eCollection 2013.
An association between pollen count (Poaceae) and symptoms is well known, but to a lesser degree the importance of priming and lag effects. Also, threshold levels for changes in symptom severity need to be validated. The present study aims to investigate the relationship between pollen counts, symptoms and health related quality of life (HRQL), and to validate thresholds levels, useful in public pollen warnings.
Children aged 7-18 with grass pollen allergy filled out a symptom diary during the pollen season for nose, eyes and lung symptoms, as well as a HRQL questionnaire every week. Pollen counts were monitored using a volumetric spore trap.
89 (91%) of the included 98 children completed the study. There was a clear association between pollen count, symptom severity and HRQL during the whole pollen season, but no difference in this respect between early and late pollen season. There was a lag effect of 1-3 days after pollen exposure except for lung symptoms. We found only two threshold levels, at 30 and 80 pollen grains/m(3) for the total symptom score, not three as is used today. The nose and eyes reacted to low doses, but for the lung symptoms, symptom strength did hardly change until 50 pollen grains/m(3).
Grass pollen has an effect on symptoms and HRQL, lasting up to 5 days after exposure. Symptoms from the lungs appear to have higher threshold levels than the eyes and the nose. Overall symptom severity does not appear to change during the course of season. Threshold levels need to be revised. We suggest a traffic light model for public pollen warnings directed to children, where green signifies "no problem", yellow signifies "can be problems, especially if you are highly sensitive" and red signifies "alert - take action".
花粉计数（禾本科）与症状之间的关联众所周知，但致敏和滞后效应的重要性较小。此外，还需要验证症状严重程度变化的阈值水平。本研究旨在调查花粉计数、症状和健康相关生活质量（HRQL）之间的关系，并验证阈值水平，这些水平对公共花粉预警有用。
患有草花粉过敏的 7-18 岁儿童在花粉季节期间填写了鼻、眼和肺症状的症状日记，以及每周一次的 HRQL 问卷。使用容量孢子陷阱监测花粉计数。
98 名纳入研究的儿童中有 89 名（91%）完成了研究。在整个花粉季节，花粉计数、症状严重程度和 HRQL 之间存在明显的关联，但在花粉季节早期和晚期之间没有区别。花粉暴露后 1-3 天出现滞后效应，但肺症状除外。我们只发现了两个阈值水平，即总症状评分的 30 和 80 花粉粒/m(3)，而不是今天使用的三个。鼻子和眼睛对低剂量有反应，但对于肺部症状，直到 50 花粉粒/m(3)时，症状强度几乎没有变化。
草花粉对症状和 HRQL 有影响，暴露后可持续长达 5 天。与眼睛和鼻子相比，肺部症状的阈值水平似乎更高。整个季节的症状严重程度似乎没有变化。阈值水平需要修订。我们建议针对儿童的公共花粉预警采用红绿灯模型，其中绿色表示“没有问题”，黄色表示“可能有问题，尤其是如果你非常敏感”，红色表示“警报-采取行动”。
