Jacomini André Mourão, de Souza Hugo Celso Dutra, Dias Danielle da Silva, Brito Janaina de Oliveira, Pinheiro Lucas Cezar, da Silva Anderson Bernardino, da Silva Roberta Fernanda, Trapé Atila Alexandre, De Angelis Kátia, Tanus-Santos José Eduardo, do Amaral Sandra Lia, Zago Anderson Saranz
Ribeirao Preto Medical School, University of Sao Paulo (USP), Avenida Bandeirantes 3900, 14049-900 Ribeirao Preto, SP, Brazil.
Translational Physiology Laboratory, Universidade Nove de Julho (UNINOVE), Rua Vergueiro 235/249, Liberdade, 01504-001 Sao Paulo, SP, Brazil.
Oxid Med Cell Longev. 2015;2015:8262383. doi: 10.1155/2016/8262383. Epub 2015 Dec 1.
The purpose of this study was to evaluate the influence of functional fitness and oxidative capacity on the nitric oxide concentration associated with hemodynamic control in older adult women. The sample consisted of 134 women (65.73 ± 6.14 years old). All subjects underwent a physical examination to assess body mass index, waist-hip ratio, body fat measurement by dual energy X-ray absorptiometry, and blood pressure (BP). Training status (TS) was evaluated by indirect determination of maximal oxygen uptake by a treadmill test using Balke protocol modified for older adults. Functional fitness was also evaluated through a "Functional Fitness Battery Test" to determine the general fitness functional index (GFFI). All participants were separated according to the functional fitness (TS1, very weak and weak; TS2, regular; TS3, good and very good). Plasma blood samples were used to evaluate prooxidant and antioxidant activity and nitrite and nitrate concentrations. The general results of this study showed that good levels of TS were related to lower levels of lipoperoxidation and protein damage, higher levels of antioxidant, and higher concentration of nitrite and nitrate. This combination may be responsible for the lower levels of BP in subjects with better TS.
本研究的目的是评估功能适应性和氧化能力对老年女性血流动力学控制相关一氧化氮浓度的影响。样本包括134名女性（65.73±6.14岁）。所有受试者均接受了体格检查，以评估体重指数、腰臀比、通过双能X线吸收法测量体脂以及血压（BP）。通过使用针对老年人修改的巴尔克方案进行跑步机测试间接测定最大摄氧量来评估训练状态（TS）。还通过“功能适应性电池测试”评估功能适应性，以确定总体适应性功能指数（GFFI）。所有参与者根据功能适应性进行分组（TS1，非常虚弱和虚弱；TS2，正常；TS3，良好和非常良好）。采集血浆样本以评估促氧化和抗氧化活性以及亚硝酸盐和硝酸盐浓度。本研究的总体结果表明，良好的TS水平与较低的脂质过氧化和蛋白质损伤水平、较高的抗氧化剂水平以及较高的亚硝酸盐和硝酸盐浓度相关。这种组合可能是TS较好的受试者血压较低的原因。
