Jacomini André M, Dias Danielle da Silva, Brito Janaina de Oliveira, da Silva Roberta F, Monteiro Henrique L, Llesuy Susana, De Angelis Kátia, Amaral Sandra L, Zago Anderson S
Department of Physical Education, School of Science, São Paulo State University Bauru, Brazil.
Translational Physiology Laboratory, Universidade Nove de Julho São Paulo, Brazil.
Front Physiol. 2017 Mar 7;8:122. doi: 10.3389/fphys.2017.00122. eCollection 2017.
The purpose of this study was to compare the association between anti and pro-oxidant activity, nitrite concentration, and blood pressure (BP) in middle-aged and older women with different levels of estimated training status (TS). The sample consisted of 155 females (50-84 years) who were submitted to a physical examination to evaluate estimated TS through the "Functional Fitness Battery Test," BP measurements, and plasma blood samples to evaluate pro-oxidant and antioxidant activity and nitrite concentrations. Participants were separated by age into a middle-aged group (<65 years) and an older (≥65 years) group and then subdivided in each group according to TS. Blood biochemistry was similar between groups. On the other hand, protein oxidation was lower in participants with higher TS, independent of age. Older females with higher TS presented higher nitrite concentrations, lower lipoperoxidation, and lower values of BP compared with those with lower TS. Lower GPx activity was observed in participants with higher TS compared with middle-aged with lower TS. Thus, our results suggest that good levels of TS may be associated with lower oxidative stress and higher nitrite concentration and may contribute to maintain normal or reduced blood pressure values.
本研究的目的是比较不同估计训练状态（TS）水平的中老年女性中抗氧化和促氧化活性、亚硝酸盐浓度与血压（BP）之间的关联。样本包括155名女性（50 - 84岁），她们接受了体格检查，通过“功能体能测试组”评估估计的TS，测量血压，并采集血浆血样以评估促氧化和抗氧化活性以及亚硝酸盐浓度。参与者按年龄分为中年组（<65岁）和老年组（≥65岁），然后在每组中再根据TS进行细分。各组之间血液生化指标相似。另一方面，TS较高的参与者蛋白质氧化较低，与年龄无关。与TS较低的老年女性相比，TS较高的老年女性亚硝酸盐浓度更高，脂质过氧化更低，血压值也更低。与TS较低的中年女性相比，TS较高的参与者谷胱甘肽过氧化物酶（GPx）活性较低。因此，我们的结果表明，良好的TS水平可能与较低的氧化应激和较高的亚硝酸盐浓度相关，并可能有助于维持正常或降低的血压值。
