• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

线粒体网络形态:构建一个综合的、几何的视角。

Mitochondrial network morphology: building an integrative, geometrical view.

机构信息

Department of Developmental and Cell Biology and Center for Complex Biological Systems, University of California, Irvine, CA 92697, USA.

出版信息

BMC Biol. 2013 Jun 24;11:71. doi: 10.1186/1741-7007-11-71.

DOI:10.1186/1741-7007-11-71
PMID:23800141
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3691739/
Abstract

The morphology of mitochondrial networks is complex and highly varied, yet vital to cell function. The first step toward an integrative understanding of how mitochondrial morphology is generated and regulated is to define the interdependent geometrical features and their dynamics that together generate the morphology of a mitochondrial network within a cell. Distinct aspects of the size, shape, position, and dynamics of mitochondrial networks are described and examples of how these features depend on one another discussed.

摘要

线粒体网络的形态复杂多样,但对细胞功能至关重要。要综合理解线粒体形态的产生和调节机制,首先要确定共同生成细胞内线粒体网络形态的相互依存的几何特征及其动态。本文描述了线粒体网络大小、形状、位置和动态的不同方面,并讨论了这些特征之间的相互依赖关系的实例。

相似文献

1
Mitochondrial network morphology: building an integrative, geometrical view.线粒体网络形态:构建一个综合的、几何的视角。
BMC Biol. 2013 Jun 24;11:71. doi: 10.1186/1741-7007-11-71.
2
Mitochondrial dynamics: Shaping and remodeling an organelle network.线粒体动态:塑造和重塑细胞器网络。
Curr Opin Cell Biol. 2021 Feb;68:28-36. doi: 10.1016/j.ceb.2020.08.014. Epub 2020 Sep 19.
3
Determining the shape and cellular distribution of mitochondria: the integration of multiple activities.确定线粒体的形状和细胞分布:多种活动的整合。
Curr Opin Cell Biol. 2013 Aug;25(4):471-6. doi: 10.1016/j.ceb.2013.02.011. Epub 2013 Mar 13.
4
Following mitochondria dynamism: confocal analysis of the organelle morphology.追踪线粒体动态变化:细胞器形态的共聚焦分析
Methods Mol Biol. 2015;1241:153-61. doi: 10.1007/978-1-4939-1875-1_13.
5
Mito Hacker: a set of tools to enable high-throughput analysis of mitochondrial network morphology.线粒体黑客:一组工具,可实现线粒体网络形态的高通量分析。
Sci Rep. 2020 Nov 3;10(1):18941. doi: 10.1038/s41598-020-75899-5.
6
Mitochondrial morphology is altered in atrophied skeletal muscle of aged mice.老年小鼠萎缩骨骼肌中的线粒体形态发生改变。
Oncotarget. 2015 Jul 20;6(20):17923-37. doi: 10.18632/oncotarget.4235.
7
The changing shape of mitochondrial apoptosis.线粒体凋亡形态的变化
Trends Endocrinol Metab. 2009 Aug;20(6):287-94. doi: 10.1016/j.tem.2009.03.007. Epub 2009 Jul 31.
8
Dynamics of mitochondrial morphology in healthy cells and during apoptosis.健康细胞及细胞凋亡过程中线粒体形态的动态变化。
Cell Death Differ. 2003 Aug;10(8):870-80. doi: 10.1038/sj.cdd.4401260.
9
The role of compartmentalized signaling pathways in the control of mitochondrial activities in cancer cells.分室信号通路在癌细胞中线粒体活性调控中的作用。
Biochim Biophys Acta Rev Cancer. 2018 Apr;1869(2):293-302. doi: 10.1016/j.bbcan.2018.04.004. Epub 2018 Apr 17.
10
Mitochondrial fusion is essential for steroid biosynthesis.线粒体融合对于类固醇生物合成至关重要。
PLoS One. 2012;7(9):e45829. doi: 10.1371/journal.pone.0045829. Epub 2012 Sep 21.

引用本文的文献

1
Mitochondrial morphological aberrations and redistribution in podocytes with glomerular diseases.肾小球疾病中足细胞的线粒体形态异常与重新分布
Ren Fail. 2025 Dec;47(1):2515528. doi: 10.1080/0886022X.2025.2515528. Epub 2025 Jul 9.
2
Amyloid-induced mitochondrial network disruption in neurons monitored by STED super-resolution imaging.通过受激发射损耗(STED)超分辨率成像监测淀粉样蛋白诱导的神经元线粒体网络破坏。
Front Cell Dev Biol. 2025 Jun 10;13:1610204. doi: 10.3389/fcell.2025.1610204. eCollection 2025.
3
A data-driven model for mitochondrial inner membrane remodeling as a driving force of organelle shaping.

本文引用的文献

1
Optimal dynamics for quality control in spatially distributed mitochondrial networks.空间分布线粒体网络中质量控制的最优动力学。
PLoS Comput Biol. 2013;9(7):e1003108. doi: 10.1371/journal.pcbi.1003108. Epub 2013 Jul 11.
2
Mitochondrial association, protein phosphorylation, and degradation regulate the availability of the active Rab GTPase Ypt11 for mitochondrial inheritance.线粒体关联、蛋白质磷酸化和降解调节活性 Rab GTPase Ypt11 用于线粒体遗传的可用性。
Mol Biol Cell. 2013 Apr;24(8):1185-95. doi: 10.1091/mbc.E12-12-0848. Epub 2013 Feb 20.
3
An actin-dependent step in mitochondrial fission mediated by the ER-associated formin INF2.
一种以数据为驱动的线粒体内膜重塑模型,作为细胞器塑形的驱动力。
J Cell Sci. 2025 Jun 15;138(12). doi: 10.1242/jcs.263850. Epub 2025 Jun 20.
4
The promise of mitochondria in the treatment of glioblastoma: a brief review.线粒体在胶质母细胞瘤治疗中的前景:简要综述
Discov Oncol. 2025 Feb 9;16(1):142. doi: 10.1007/s12672-025-01891-y.
5
Mitochondrial Fragmentation as a Key Driver of Neurodegenerative Disease.线粒体碎片化作为神经退行性疾病的关键驱动因素
Curr Alzheimer Res. 2024;21(9):607-614. doi: 10.2174/0115672050366194250107050650.
6
A fully automated morphological analysis of yeast mitochondria from wide-field fluorescence images.基于宽场荧光图像的酵母线粒体全自动形态分析。
Sci Rep. 2024 Dec 3;14(1):30144. doi: 10.1038/s41598-024-81241-0.
7
Adenosine diphosphate released from stressed cells triggers mitochondrial transfer to achieve tissue homeostasis.应激细胞释放的二磷酸腺苷触发线粒体转移以实现组织内稳态。
PLoS Biol. 2024 Aug 20;22(8):e3002753. doi: 10.1371/journal.pbio.3002753. eCollection 2024 Aug.
8
Mitochondria in COVID-19: from cellular and molecular perspective.新型冠状病毒肺炎中的线粒体:从细胞和分子角度看
Front Physiol. 2024 Jun 21;15:1406635. doi: 10.3389/fphys.2024.1406635. eCollection 2024.
9
Beyond fission and fusion-Diving into the mysteries of mitochondrial shape.超越裂变与融合——深入探究线粒体形态的奥秘。
PLoS Biol. 2024 Jul 1;22(7):e3002671. doi: 10.1371/journal.pbio.3002671. eCollection 2024 Jul.
10
Uncovering the impact of UV radiation on mitochondria in dermal cells: a STED nanoscopy study.揭示紫外线辐射对皮肤细胞中线粒体的影响:基于 STED 纳米显微镜的研究。
Sci Rep. 2024 Apr 15;14(1):8675. doi: 10.1038/s41598-024-55778-z.
由 ER 相关形态发生因子 INF2 介导的线粒体裂变中的肌动蛋白依赖步骤。
Science. 2013 Jan 25;339(6118):464-7. doi: 10.1126/science.1228360.
4
Endoplasmic reticulum-associated mitochondria-cortex tether functions in the distribution and inheritance of mitochondria.内质网相关的线粒体-皮质连接在维持线粒体的分布和遗传中发挥作用。
Proc Natl Acad Sci U S A. 2013 Feb 5;110(6):E458-67. doi: 10.1073/pnas.1215232110. Epub 2013 Jan 22.
5
Mitochondrial network size scaling in budding yeast.酵母出芽过程中线粒体网络大小的缩放。
Science. 2012 Nov 9;338(6108):822-4. doi: 10.1126/science.1225720.
6
Emergence of the mitochondrial reticulum from fission and fusion dynamics.线粒体网状结构的起源:来自分裂和融合动力学。
PLoS Comput Biol. 2012;8(10):e1002745. doi: 10.1371/journal.pcbi.1002745. Epub 2012 Oct 25.
7
Deceleration of fusion-fission cycles improves mitochondrial quality control during aging.衰老过程中融合-裂变循环的减速可改善线粒体质量控制。
PLoS Comput Biol. 2012;8(6):e1002576. doi: 10.1371/journal.pcbi.1002576. Epub 2012 Jun 28.
8
The many faces of mitochondrial autophagy: making sense of contrasting observations in recent research.线粒体自噬的多面性:解读近期研究中的矛盾观察结果
Int J Cell Biol. 2012;2012:431684. doi: 10.1155/2012/431684. Epub 2012 Apr 8.
9
Mitochondrial dynamics and their impact on T cell function.线粒体动态及其对 T 细胞功能的影响。
Cell Calcium. 2012 Jul;52(1):57-63. doi: 10.1016/j.ceca.2012.02.005. Epub 2012 Mar 14.
10
Gem1 and ERMES do not directly affect phosphatidylserine transport from ER to mitochondria or mitochondrial inheritance.Gem1 和 ERMES 并不直接影响磷脂酰丝氨酸从内质网向线粒体的运输或线粒体的遗传。
Traffic. 2012 Jun;13(6):880-90. doi: 10.1111/j.1600-0854.2012.01352.x. Epub 2012 Apr 8.