Department of Microbiology and Cell Science, University of Florida , Gainesville, FL , USA.
Front Immunol. 2013 Jun 19;4:156. doi: 10.3389/fimmu.2013.00156. eCollection 2013.
Leishmaniasis is a complex disease that is caused by parasites of the Leishmania genus. Leishmania are further classified into several complexes, each of which can engage in distinct interactions with mammalian hosts resulting in differing disease presentations. It is therefore not unexpected that host immune responses to Leishmania are variable. The induction of interferon gamma (IFN-γ) and response to it in these infections has received considerable attention. In this review, we summarize our current understanding of some of the host responses during Leishmania infections that are regulated by IFN-γ. In addition, studies that explore the nature of parasite-derived molecular mediators that might affect the host response to IFN-γ are also discussed.
利什曼病是一种复杂的疾病，由利什曼原虫属的寄生虫引起。利什曼原虫进一步分为几个复合物，每个复合物都可以与哺乳动物宿主进行不同的相互作用，导致不同的疾病表现。因此，宿主对利什曼原虫的免疫反应是可变的，这并不奇怪。在这些感染中，干扰素 γ（IFN-γ）的诱导及其对其的反应受到了相当多的关注。在这篇综述中，我们总结了我们目前对 IFN-γ调节的利什曼原虫感染过程中一些宿主反应的理解。此外，还讨论了研究寄生虫衍生的分子介质的性质，这些分子介质可能影响宿主对 IFN-γ的反应。
