The Xuzhou Center for Disease Control and Prevention, 142 West Erhuan Road, Xuzhou City, Jiangsu Province, People's Republic of China 221006.
BMC Fam Pract. 2013 Jun 27;14:91. doi: 10.1186/1471-2296-14-91.
Cigarette smoking is the major risk factor for chronic obstructive pulmonary disease (COPD). But a fewer smoking cessation measures were conducted in communities for smokers with COPD in China. The aim of our study was to assess the preventive effects of behavioral interventions for smoking cessation and potential impact factors in smokers with COPD in China.
In a randomised controlled smoking cessation trial 3562 patients with COPD who were current smoker were allocated to intervention group received behavioral intervention and control group received the usual care for two years. The primary efficacy endpoint was the complete and continuous abstinence from smoking from the beginning of month 24 to the end of month 30. Participants were followed up at month 48.
Continuous smoking abstinence rates from month 24 to 30 were significantly higher in participants receiving behavioral intervention than in those receiving usual care (46.4% vs 3.4%, p < 0.001). Continuous abstinence rates from months 24 to 36 (45.8% vs 4.0%) and months 24 to 48 (44.3% vs 5.1%) were also higher in participants receiving behavioral intervention than in those control group. Family members or family physicians/nurses smoking were first identified to influence smoking cessation.
Behavioral intervention doubled the smoking cessation rate in patients with COPD and was complied well by the general practitioners. The family members and family physicians/nurses smoking were the main risk factors for smoking cessation.
Chinese Clinical Trials Registration (ChiCTR-TRC-12001958).
吸烟是慢性阻塞性肺疾病（COPD）的主要危险因素。但在中国，针对 COPD 吸烟者的社区戒烟措施较少。我们的研究旨在评估针对中国 COPD 吸烟者的行为干预戒烟措施的预防效果及其潜在影响因素。
在一项随机对照戒烟试验中，将 3562 名当前吸烟的 COPD 患者分为干预组（接受行为干预）和对照组（接受常规护理），随访 48 个月。主要疗效终点是从第 24 个月到第 30 个月完全持续戒烟。
接受行为干预的参与者从第 24 个月到第 30 个月的持续吸烟戒断率明显高于接受常规护理的参与者（46.4%比 3.4%，p<0.001）。从第 24 个月到第 36 个月（45.8%比 4.0%）和第 24 个月到第 48 个月（44.3%比 5.1%），接受行为干预的参与者的持续戒断率也更高。研究首次发现，家庭成员或家庭医生/护士吸烟是影响戒烟的主要因素。
行为干预将 COPD 患者的戒烟率提高了一倍，且被全科医生很好地遵循。家庭成员和家庭医生/护士吸烟是戒烟的主要危险因素。
中国临床试验注册中心（ChiCTR-TRC-12001958）。
