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万次鼠标点击之后:十年来收集的支持药物研发的精选在线资源。

One hundred thousand mouse clicks down the road: selected online resources supporting drug discovery collected over a decade.

机构信息

Université Paris Diderot, Sorbonne Paris Cité, Inserm UMR-S 973, Molécules Thérapeutiques In Silico, 39 rue Helene Brion, 75013 Paris, France.

出版信息

Drug Discov Today. 2013 Nov;18(21-22):1081-9. doi: 10.1016/j.drudis.2013.06.013. Epub 2013 Jul 3.

Abstract

Online resources enabling and supporting drug discovery have blossomed during the past ten years. However, drug hunters commonly find themselves overwhelmed by the proliferation of these computer-based resources. Ten years ago, we, the authors of this review, felt that a comprehensive list of in silico resources relating to drug discovery was needed. Especially because the internet provides a wealth of inspiring tools that, if fully exploited, could greatly assist the process. We present here a compilation of online tools and databases collected over the past decade. The tools were essentially found through literature and internet searches and, currently, our list contains over 1500 URLs. We also briefly highlight some recently reported services and comment about ongoing and future efforts in the field.

摘要

在过去的十年中,支持药物发现的在线资源如雨后春笋般涌现。然而,药物研究人员常常发现自己淹没在这些基于计算机的资源的泛滥之中。十年前,我们——本篇综述的作者,认为需要一个全面的与药物发现相关的计算资源清单。特别是因为互联网提供了丰富的灵感工具,如果充分利用,将极大地帮助这个过程。我们在这里展示了过去十年中收集的在线工具和数据库的汇编。这些工具主要是通过文献和互联网搜索找到的,目前,我们的清单包含了 1500 多个 URL。我们还简要介绍了一些最近报道的服务,并评论了该领域正在进行和未来的工作。

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