Aspetar - Qatar Orthopaedic and Sports Medicine Hospital, Research and Education Centre, Doha, Qatar.
School of Human Movement Studies, University of Queensland, Brisbane, Australia.
Int J Sports Med. 2014 Jan;35(1):8-13. doi: 10.1055/s-0033-1333746. Epub 2013 Jul 9.
This study examined the influence of training volume on resting and exercise-induced plasma markers of oxidative stress (MDA concentration) and antioxidant status (GPX, CAT & SOD erythrocyte activities). Moderately trained participants (TG) (n=6; 4 males and 2 females; 25±1.8 years) and sedentary control subjects (CG) participated in the 8-week investigation. The TG increased their training volume from ~4.9 to ~18 h.wk-1 by the end of the investigation. Before the increase in training volume and at 2-week intervals the TG completed a 30 km cycling time trial (TT30) where resting-and post-exercise blood was -sampled and analysed for oxidative stress and antioxidant status. The CG had their resting blood sampled and analysed fortnightly. The data showed that TT30 performance improved in the first 4 weeks but remained unchanged in the last 4. Resting plasma MDA and CAT increased in response to training, with no change in the resting activities of erythrocyte GPX and SOD. Post-TT30 MDA and CAT increased over the training period and training hours positively related to both resting-and post-TT30 MDA. The increase in resting MDA and the up-regulation in CAT in response to an increased training volume may have a role in the identification of a training and performance plateau.
本研究考察了训练量对静息和运动诱导的氧化应激血浆标志物（MDA 浓度）和抗氧化状态（GPX、CAT 和 SOD 红细胞活性）的影响。经过 8 周的调查，中度训练组（TG）（n=6；4 男 2 女；25±1.8 岁）和久坐对照组（CG）参与了研究。TG 通过增加训练量，使训练量从约 4.9 小时/周增加到约 18 小时/周。在增加训练量之前和每两周一次，TG 完成了 30 公里的自行车计时赛（TT30），在此期间采集了静息和运动后的血液样本，并分析了氧化应激和抗氧化状态。CG 每两周采集一次静息血液样本并进行分析。结果显示，TT30 的表现在前 4 周有所提高，但在后 4 周保持不变。静息状态下的血浆 MDA 和 CAT 随着训练而增加，红细胞 GPX 和 SOD 的静息活性没有变化。TT30 后，MDA 和 CAT 在整个训练期间增加，训练时间与静息和 TT30 后 MDA 都呈正相关。静息 MDA 的增加和 CAT 的上调可能在识别训练和表现高原期方面发挥作用。
