Galen Research Ltd, Manchester, United Kingdom.
BMC Pulm Med. 2013 Jul 12;13:45. doi: 10.1186/1471-2466-13-45.
The Cambridge Pulmonary Hypertension Outcome Review (CAMPHOR) and the Medical Outcomes Study Short Form 36 (SF-36) are widely used to assess patient-reported outcome in individuals with pulmonary hypertension (PH). The aim of the study was to compare the psychometric properties of the two measures.
Participants were recruited from specialist PH centres in Australia and New Zealand. Participants completed the CAMPHOR and SF-36 at two time points two weeks apart. The SF-36 is a generic health status questionnaire consisting of 36 items split into 8 sections. The CAMPHOR is a PH-specific measure consisting of 3 scales; symptoms, activity limitations and needs-based QoL. The questionnaires were assessed for distributional properties (floor and ceiling effects), internal consistency (Cronbach's alpha), test-retest reliability and construct validity (scores by World Health Organisation functional classification).
The sample comprised 65 participants (mean (SD) age = 57.2 (14.5) years; n(%) male = 14 (21.5%)). Most of the patients were in WHO class 2 (27.7%) and 3 (61.5%). High ceiling effects were observed for the SF-36 bodily pain, social functioning and role emotional domains. Test-retest reliability was poor for six of the eight SF-36 domains, indicating high levels of random measurement error. Three of the SF-36 domains did not distinguish between WHO classes. In contrast, all CAMPHOR scales exhibited good distributional properties, test retest reliability and distinguished between WHO functional classes.
The CAMPHOR exhibited superior psychometric properties, compared with the SF-36, in the assessment of PH patient-reported outcome.
剑桥肺高血压结局回顾（CAMPHOR）和医疗结局研究短表 36（SF-36）被广泛用于评估肺高血压（PH）患者的报告结局。本研究旨在比较两种测量方法的心理测量特性。
参与者从澳大利亚和新西兰的专业 PH 中心招募。参与者在两周的两个时间点完成了 CAMPHOR 和 SF-36。SF-36 是一个通用的健康状况问卷，由 36 个项目组成，分为 8 个部分。CAMPHOR 是一种特定于 PH 的测量方法，由 3 个量表组成：症状、活动受限和基于需求的 QoL。问卷评估了分布特性（地板和天花板效应）、内部一致性（Cronbach's alpha）、测试-重测可靠性和结构有效性（按世界卫生组织功能分类的分数）。
该样本包括 65 名参与者（平均（SD）年龄=57.2（14.5）岁；n（%）男性=14（21.5%））。大多数患者处于世界卫生组织功能分类 2 级（27.7%）和 3 级（61.5%）。SF-36 身体疼痛、社会功能和角色情感领域存在较高的天花板效应。八个 SF-36 领域中有六个领域的测试-重测可靠性较差，表明存在较高的随机测量误差。SF-36 的三个领域无法区分 WHO 功能分类。相比之下，CAMPHOR 的所有量表都表现出良好的分布特性、测试-重测可靠性，并能区分 WHO 功能分类。
与 SF-36 相比，CAMPHOR 在评估 PH 患者报告结局方面具有更好的心理测量特性。
