Department of Chemistry, Faculty of Medical Sciences, University of Niš, Bul. dr Zorana Ðinđića 81, RS-18000 Niš.
Chem Biodivers. 2013 Jul;10(7):1335-49. doi: 10.1002/cbdv.201200332.
Characterization by GC-FID and GC/MS analyses of the Stachys officinalis (L.) Trevis. essential oil obtained by hydrodistillation of the aerial parts allowed the identification of 190 components that represented 97.9% of the total oil content. The main constituents identified were germacrene D (19.9%), β-caryophyllene (14.1%), and α-humulene (7.5%). Terpenoids were by far predominant (89.4%), with sesquiterpene hydrocarbons (69.1%) and oxygenated sesquiterpenes (14.8%) being the most abundant compounds detected in the oil. Based on the present and previously published results, multivariate statistical comparison of the chemical composition of the essential oils was performed within the species. Principal component analysis (PCA) and agglomerative hierarchical clustering (AHC) of the data on the volatile profiles of S. officinalis taxa revealed no pronounced differences among the samples originated from the Balkan Peninsula. Additionally, the oil was screened for in vitro antibacterial and antifungal activity using the broth microdilution assay. The oil's best antimicrobial activities were obtained against the mold Aspergillus niger (minimal inhibitory (MIC) and minimal fungicidal (MFC) concentrations of 2.5 and 5.0 mg/ml, resp.) and the yeast Candida albicans (MIC and MFC of 5.0 mg/ml).
采用 GC-FID 和 GC/MS 分析对水蒸馏法提取的穗花薰衣草（L.）Trevis 的地上部分精油进行了表征，鉴定出 190 种成分，占总油含量的 97.9%。鉴定出的主要成分是大根香叶烯 D（19.9%）、β-石竹烯（14.1%）和α-葎草烯（7.5%）。萜类化合物是迄今为止的主要成分（89.4%），检测到的油中含量最多的化合物是倍半萜烃（69.1%）和含氧倍半萜（14.8%）。基于目前和以前发表的结果，对该物种的精油化学成分进行了多元统计比较。对穗花薰衣草分类群挥发物图谱数据的主成分分析（PCA）和凝聚层次聚类（AHC）表明，来自巴尔干半岛的样本之间没有明显差异。此外，还采用肉汤微量稀释法测定了该油的体外抗菌和抗真菌活性。该油对霉菌黑曲霉（最小抑菌（MIC）和最小杀菌（MFC）浓度分别为 2.5 和 5.0 mg/ml）和酵母白色念珠菌（MIC 和 MFC 为 5.0 mg/ml）的抗菌活性最好。
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