Department of Chemistry, Yuvaraja's College, University of Mysore, Mysore 570 005, India.
Bioorg Med Chem Lett. 2013 Aug 15;23(16):4532-9. doi: 10.1016/j.bmcl.2013.06.042. Epub 2013 Jun 22.
A novel series of pyrazoline amidoxime (2a-d) and pyrazoly-1,2,4-oxadiazole (3a-p) and (4) of pharmacological significance have been synthesised. Structures of newly synthesised compounds were characterized by spectral studies. New compounds were screened for their in vitro antioxidant, antimicrobial and antiinflammatory activities. Among the synthesized compounds, compound 2a, 3l and 3o were found to be active antimicrobial agents in addition to having potent antioxidant activity, while the compound 3f showed promising antiinflammatory activity in comparison with standard drug.
已经合成了一系列具有药理学意义的新型吡唑啉缩氨肟（2a-d）和吡唑并[1,2,4]恶二唑（3a-p）和（4）。新合成化合物的结构通过光谱研究进行了表征。新化合物进行了体外抗氧化、抗菌和抗炎活性筛选。在所合成的化合物中，化合物 2a、3l 和 3o 除了具有很强的抗氧化活性外，还被发现是有效的抗菌剂，而化合物 3f 与标准药物相比显示出有希望的抗炎活性。
