Azemati Mahbobe, Shakerhosseini Rahebe, Hekmatdos Azita, Alavi-Majd Hamid, Hedayati Mehdi, Houshiarrad Anahita, Hosseini Mona, Taherian Mohammad E, Noroozi Mohammad F, Rashidi Maryam, Amraie Akram
Department of Nutrition Research, National Nutrition and Food Technology Research Institute, Tehran, Iran.
J Res Med Sci. 2012 Dec;17(12):1137-43.
Recently, omega-3 fatty acids are in the center of attention for their potent anti-inflammatory effects. Osteoporosis as a chronic senile disease is associated with inflammation, and the role of inflammatory mediators has been demonstrated in the recent years. The beneficial effects of n-3 fatty acids on bone were proven in many animal studies, while to date, no conclusive data is available in human. The aim of this study was to evaluate the impact of n-3 fatty acids on bone biomarkers in osteoporotic women.
Forty osteoporotic post-menopausal women were recruited in the study and randomized in receiving either 40 g canola oil or the same amount sunflower oil per day as their dietary oil for 3 months. Serum levels of osteocalcin, bone alkaline phosphatase (BALP), N telo peptide collagen (NTX) and 25- hydroxy vitamin D3 were measured at baseline and at the end of the third month in both groups.
In the canola oil group, BALP and NTX were increased after 3 months while Osteocalcin decreased in both groups slightly; however,none of these changes were significant. In both groups, serum vitamin D3 was increased significantly; however, this change between groups was not significant.
Canola oil did not affect bone formation and resorption significantly after 3 months consumption. Further investigations with longer follow up are recommended.
最近，ω-3脂肪酸因其强大的抗炎作用而备受关注。骨质疏松症作为一种慢性老年疾病与炎症相关，近年来炎症介质的作用已得到证实。许多动物研究证实了n-3脂肪酸对骨骼有益，然而，迄今为止，尚无关于人类的确凿数据。本研究的目的是评估n-3脂肪酸对骨质疏松症女性骨生物标志物的影响。
本研究招募了40名绝经后骨质疏松症女性，并将她们随机分为两组，一组每天食用40克菜籽油作为食用油，另一组每天食用等量的向日葵油，为期3个月。在基线和第三个月末，测量两组血清骨钙素、骨碱性磷酸酶（BALP）、N端肽胶原（NTX）和25-羟基维生素D3水平。
在菜籽油组中，3个月后BALP和NTX升高，而两组骨钙素均略有下降；然而，这些变化均无统计学意义。两组血清维生素D3均显著升高；然而，两组间的这种变化无统计学意义。
食用3个月菜籽油后，对骨形成和骨吸收无显著影响。建议进行更长时间随访的进一步研究。
