蛋白质酪氨酸磷酸酶：结构、功能及在人类疾病中的意义。
Protein tyrosine phosphatases: structure, function, and implication in human disease.
作者信息
Tautz Lutz, Critton David A, Grotegut Stefan
机构信息
Infectious and Inflammatory Disease Center, Sanford-Burnham Medical Research Institute, La Jolla, CA, USA.
出版信息
Methods Mol Biol. 2013;1053:179-221. doi: 10.1007/978-1-62703-562-0_13.
Abstract
Protein tyrosine phosphorylation is a key regulatory mechanism in eukaryotic cell physiology. Aberrant expression or function of protein tyrosine kinases and protein tyrosine phosphatases can lead to serious human diseases, including cancer, diabetes, as well as cardiovascular, infectious, autoimmune, and neuropsychiatric disorders. Here, we give an overview of the protein tyrosine phosphatase superfamily with its over 100 members in humans. We review their structure, function, and implications in human diseases, and discuss their potential as novel drug targets, as well as current challenges and possible solutions to developing therapeutics based on these enzymes.
摘要
蛋白质酪氨酸磷酸化是真核细胞生理学中的关键调节机制。蛋白质酪氨酸激酶和蛋白质酪氨酸磷酸酶的异常表达或功能可导致严重的人类疾病，包括癌症、糖尿病以及心血管、感染性、自身免疫性和神经精神疾病。在此，我们概述了人类中拥有100多个成员的蛋白质酪氨酸磷酸酶超家族。我们回顾了它们的结构、功能及其在人类疾病中的意义，并讨论了它们作为新型药物靶点的潜力，以及基于这些酶开发治疗方法目前面临的挑战和可能的解决方案。
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