Robert Kertzer Exercise Physiology Laboratory, University of New Hampshire, Durham, NH, USA,
Eur J Appl Physiol. 2013 Oct;113(10):2577-86. doi: 10.1007/s00421-013-2693-9. Epub 2013 Jul 20.
The purpose of this study was to determine the effect of cryotherapy on the inflammatory response to muscle-damaging exercise using a randomized trial. Twenty recreationally active males completed a 40-min run at a -10 % grade to induce muscle damage. Ten of the subjects were immersed in a 5 °C ice bath for 20 min and the other ten served as controls. Knee extensor peak torque, soreness rating, and thigh circumference were obtained pre- and post-run, and 1, 6, 24, 48, and 72 h post-run. Blood samples were obtained pre- and post-run, and 1, 6 and 24 h post-run for assay of plasma chemokine ligand 2 (CCL2). Peak torque decreased from 270 ± 57 Nm at baseline to 253 ± 65 Nm post-run and increased to 295 ± 68 Nm by 72 h post-run with no differences between groups (p = 0.491). Soreness rating increased from 3.6 ± 6.0 mm out of 100 mm at baseline to 47.4 ± 28.2 mm post-run and remained elevated at all time points with no differences between groups (p = 0.696). CCL2 concentrations increased from 116 ± 31 pg mL(-1) at baseline to 293 ± 109 pg mL(-1) at 6 h post-run (control) and from 100 ± 27 pg mL(-1) at baseline to 208 ± 71 pg mL(-1) at 6 h post-run (cryotherapy). The difference between groups was not significant (p = 0.116), but there was a trend for lower CCL2 in the cryotherapy group at 6 h (p = 0.102), though this measure was highly variable. In conclusion, 20 min of cryotherapy was ineffective in attenuating the strength decrement and soreness seen after muscle-damaging exercise, but may have mitigated the rise in plasma CCL2 concentration. These results do not support the use of cryotherapy during recovery.
这项研究的目的是使用随机试验确定冷冻疗法对肌肉损伤运动引起的炎症反应的影响。二十名有经验的男性在-10%的坡度上完成了 40 分钟的跑步，以造成肌肉损伤。其中 10 名受试者被浸入 5°C 的冰浴中 20 分钟，而另外 10 名作为对照组。在跑步前、后以及跑步后 1、6、24、48 和 72 小时测量伸膝峰值扭矩、酸痛评分和大腿围度。在跑步前、后以及跑步后 1、6 和 24 小时采集血样，用于测定血浆趋化因子配体 2（CCL2）。峰值扭矩从基线时的 270±57 Nm 下降到跑步后的 253±65 Nm，到 72 小时后增加到 295±68 Nm，两组之间没有差异（p=0.491）。酸痛评分从基线时的 3.6±6.0 毫米（满分 100 毫米）增加到跑步后的 47.4±28.2 毫米，且在所有时间点均保持升高，两组之间没有差异（p=0.696）。CCL2 浓度从基线时的 116±31 pg mL(-1)增加到 6 小时后的 293±109 pg mL(-1)（对照组），从基线时的 100±27 pg mL(-1)增加到 6 小时后的 208±71 pg mL(-1)（冷冻疗法组）。两组之间的差异没有统计学意义（p=0.116），但冷冻疗法组在 6 小时时 CCL2 有较低的趋势（p=0.102），尽管该指标的变异性较大。总之，20 分钟的冷冻疗法不能减轻肌肉损伤运动后出现的力量下降和酸痛，但可能减轻了血浆 CCL2 浓度的升高。这些结果不支持在恢复期使用冷冻疗法。
