Center for Molecular Medicine, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA; Department of Life Science, Division of Life and Pharmaceutical Sciences, Ewha Womans University, 11-1 Daehyun-Dong Seodaemoon-Gu, Seoul, South Korea.
Curr Opin Cell Biol. 2013 Dec;25(6):724-9. doi: 10.1016/j.ceb.2013.07.002. Epub 2013 Jul 24.
There is a growing appreciation that metabolic signals are integrated and coupled to cell cycle progression. However, the molecular wiring that connects nutrient availability, biosynthetic intermediates and energetic balance to the core cell cycle machinery remains incompletely understood. In this review, we explore the recent progress in this area with particular emphasis on how nutrient and energetic status is sensed within the cell to ultimately regulate cell growth and division. The role these pathways play in normal cell function including stem cell biology is also discussed. Furthermore, we describe the growing appreciation that dysregulation of these pathways might contribute to a variety of pathological conditions including metabolic diseases and tumor formation.
人们越来越认识到，代谢信号是相互整合和耦合的，与细胞周期的进展有关。然而，将营养物质的可用性、生物合成中间体和能量平衡与核心细胞周期机制联系起来的分子连接仍然不完全清楚。在这篇综述中，我们探讨了这一领域的最新进展，特别强调了细胞内如何感知营养和能量状态，最终调节细胞生长和分裂。还讨论了这些途径在正常细胞功能中的作用，包括干细胞生物学。此外，我们描述了人们越来越认识到，这些途径的失调可能导致多种病理状况，包括代谢疾病和肿瘤形成。
