Tamminga Sietske J, Verbeek Jos H A M, Frings-Dresen Monique H W, De Boer Angela G E M
Coronel Institute of Occupational Health, Academic Medical Center, University of Amsterdam, PO Box 22700, 1100 DE, Amsterdam, The Netherlands,
Qual Life Res. 2014 Mar;23(2):515-25. doi: 10.1007/s11136-013-0484-8. Epub 2013 Jul 27.
The purpose of this study was to determine reproducibility, validity, and responsiveness of the Work Limitations Questionnaire (WLQ) among cancer survivors.
A cohort of 53 cancer survivors completed the WLQ and other questionnaires at baseline, 4-week, and 6-month follow-up. We assessed internal consistency, intraclass correlation coefficient, standard error of measurement, floor- and ceiling effects and compared the WLQ with other constructs. For responsiveness, we assessed the following anchor-based measures: minimal important change (MIC) versus smallest detectable change (SDC) and area under the curve (AUC) of receiver operation characteristic (ROC).
We found sufficient reproducibility at group level but not at individual level as the MIC (4.0) exceeded SDC at group level (3.1) but not at individual level (18.0). There was no indication of systematic bias or proportional bias. The internal consistency and construct validity for the WLQ and its subscales were sufficient or slightly less than sufficient. There was a floor effect for one subscale, but there were no ceiling effects. Responsiveness was sufficient with an AUC of a ROC of 0.65.
The WLQ is reproducible, valid, and responsive for use at group level among cancer survivors but not sufficiently reproducible for use at individual level.
本研究旨在确定工作限制问卷(WLQ)在癌症幸存者中的可重复性、有效性和反应性。
一组53名癌症幸存者在基线、4周和6个月随访时完成了WLQ及其他问卷。我们评估了内部一致性、组内相关系数、测量标准误差、地板效应和天花板效应,并将WLQ与其他结构进行了比较。对于反应性,我们评估了以下基于锚定的指标:最小重要变化(MIC)与最小可检测变化(SDC)以及接受者操作特征(ROC)曲线下面积(AUC)。
我们发现在组水平上有足够的可重复性,但在个体水平上没有,因为MIC(4.0)在组水平上超过了SDC(3.1),但在个体水平上没有(18.0)。没有系统偏差或比例偏差的迹象。WLQ及其子量表的内部一致性和结构效度足够或略低于足够水平。一个子量表存在地板效应,但没有天花板效应。反应性足够,ROC的AUC为0.65。
WLQ在癌症幸存者的组水平上具有可重复性、有效性和反应性,但在个体水平上的可重复性不足。