Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, United States.
Neurosci Res. 2013 Sep-Oct;77(1-2):97-101. doi: 10.1016/j.neures.2013.07.003. Epub 2013 Jul 26.
The adipocytokine leptin is a key mediator of energy homeostasis. Recent papers have suggested that leptin may also have roles in the brain however it is unclear whether leptin is connected to symptoms of mental disorders. In this study, we sought to clarify the relationships between serum leptin level and psychopathology in schizophrenia (SZ) patients. The severity of positive symptoms inversely correlated with the serum leptin levels among SZ patients. There was no correlation between leptin levels and negative symptoms or neurocognition. Our data suggest a role of leptin in SZ positive symptoms.
脂肪细胞因子瘦素是能量平衡的关键调节剂。最近的研究表明，瘦素在大脑中可能也具有作用，但尚不清楚瘦素是否与精神障碍的症状有关。在这项研究中，我们试图阐明精神分裂症 (SZ) 患者的血清瘦素水平与精神病理学之间的关系。SZ 患者的阳性症状严重程度与血清瘦素水平呈负相关。瘦素水平与阴性症状或神经认知无相关性。我们的数据表明瘦素在 SZ 阳性症状中起作用。
