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2011 年越南胡志明市肠道病毒 71 型的基因和抗原特征。

Genetic and antigenic characterization of enterovirus 71 in Ho Chi Minh City, Vietnam, 2011.

机构信息

Children's Hospital No. 1, Ho Chi Minh City, Vietnam.

出版信息

PLoS One. 2013 Jul 29;8(7):e69895. doi: 10.1371/journal.pone.0069895. Print 2013.

DOI:10.1371/journal.pone.0069895
PMID:23922846
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3726754/
Abstract

Enterovirus 71 (EV71) frequently causes fatal infections in young children in Asia. In 2011, EV71 epidemics occurred in southern Vietnam. We conducted genetic and antigenic analysis of the EV71 isolates and found that 94% of them were genotype C4a related to two lineages circulating in China and 6% were genotype C5 which have circulated in Vietnam since 2003. Antigenic variants were not detected. EV71 vaccines are being developed. Longitudinal enterovirus surveillance data are critical to formulate vaccination policy in Vietnam.

摘要

肠道病毒 71 型（EV71）经常导致亚洲幼儿发生致命感染。2011 年，EV71 在越南南部爆发。我们对 EV71 分离株进行了遗传和抗原性分析，发现其中 94%为与中国流行的两个谱系相关的 C4a 基因型，6%为自 2003 年以来在越南流行的 C5 基因型。未检测到抗原变异体。EV71 疫苗正在开发中。在越南制定疫苗接种政策时，需要对肠道病毒进行长期监测。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ca49/3726754/bd185e1d2349/pone.0069895.g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ca49/3726754/5dab793cf7f3/pone.0069895.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ca49/3726754/bd185e1d2349/pone.0069895.g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ca49/3726754/5dab793cf7f3/pone.0069895.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ca49/3726754/bd185e1d2349/pone.0069895.g002.jpg

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