碳水化合物驱动的纳米流控二极管：纳米管中可切换的电流整流
Carbohydrate-actuated nanofluidic diode: switchable current rectification in a nanopipette.
机构信息
Department of Biomolecular Engineering, Baskin School of Engineering at University of California Santa Cruz, 1156 High Street, Santa Cruz, CA 95064, USA.
出版信息
Nanoscale. 2013 Oct 7;5(19):9214-21. doi: 10.1039/c3nr02105j. Epub 2013 Aug 12.
Abstract
Nanofluidic structures share many properties with ligand-gated ion channels. However, actuating ion conductance in artificial systems is a challenge. We have designed a system that uses a carbohydrate-responsive polymer to modulate ion conductance in a quartz nanopipette. The cationic polymer, a poly(vinylpyridine) quaternized with benzylboronic acid groups, undergoes a transition from swollen to collapsed upon binding to monosaccharides. As a result, the current rectification in nanopipettes can be reversibly switched depending on the concentration of monosaccharides. Such molecular actuation of nanofluidic conductance may be used in novel sensors and drug delivery systems.
摘要
纳米流控结构与配体门控离子通道有许多共同特性。然而，在人工系统中调节离子电导率是一个挑战。我们设计了一个系统，该系统使用碳水化合物响应性聚合物来调节石英纳米管中的离子电导率。带正电荷的聚合物，即带有苄基硼酸基团的季化聚（4-乙烯基吡啶），在与单糖结合时从溶胀状态转变为塌陷状态。因此，根据单糖浓度，纳米管中的电流整流可以可逆切换。这种纳米流导的分子致动作用可能用于新型传感器和药物输送系统。
相似文献
1
Carbohydrate-actuated nanofluidic diode: switchable current rectification in a nanopipette.碳水化合物驱动的纳米流控二极管：纳米管中可切换的电流整流
Nanoscale. 2013 Oct 7;5(19):9214-21. doi: 10.1039/c3nr02105j. Epub 2013 Aug 12.
2
Proton-Gated Rectification Regimes in Nanofluidic Diodes Switched by Chemical Effectors.由化学效应器切换的纳米流体二极管中的质子门控整流机制。
Small. 2018 May;14(18):e1703144. doi: 10.1002/smll.201703144. Epub 2018 Feb 5.
3
Label-free electrical quantification of amplified nucleic acids through nanofluidic diodes.通过纳流控二极管对扩增核酸进行无标记的电量化。
Biosens Bioelectron. 2013 Dec 15;50:78-83. doi: 10.1016/j.bios.2013.06.013. Epub 2013 Jun 18.
4
Rectification of ion current in nanopipettes by external substrates.通过外部底物对纳米吸管中离子电流的整流作用。
ACS Nano. 2013 Dec 23;7(12):11272-11282. doi: 10.1021/nn4050485. Epub 2013 Dec 9.
5
Electrochemically Switchable Double-Gate Nanofluidic Logic Device as Biomimetic Ion Pumps.电化学可切换双门纳米流体逻辑器件作为仿生离子泵。
ACS Appl Mater Interfaces. 2021 Jul 14;13(27):32479-32485. doi: 10.1021/acsami.1c06535. Epub 2021 Jun 30.
6
An Insulin-Modified pH-Responsive Nanopipette Based on Ion Current Rectification.基于离子电流整流的胰岛素修饰 pH 响应纳米管。
Sensors (Basel). 2024 Jun 30;24(13):4264. doi: 10.3390/s24134264.
7
The Modification and Applications of Nanopipettes in Electrochemical Analysis.纳米移液器在电化学分析中的改进及应用。
Chempluschem. 2023 Jul;88(7):e202300100. doi: 10.1002/cplu.202300100.
8
Nanopipette delivery: influence of surface charge.纳米移液器递送：表面电荷的影响
Analyst. 2015 Jul 21;140(14):4835-42. doi: 10.1039/c4an01073f. Epub 2014 Aug 13.
9
Asymmetric ion transport through ion-channel-mimetic solid-state nanopores.通过类离子通道的固态纳米孔进行不对称离子传输。
Acc Chem Res. 2013 Dec 17;46(12):2834-46. doi: 10.1021/ar400024p. Epub 2013 May 28.
10
Nanofluidic diode based on branched alumina nanochannels with tunable ionic rectification.基于分支氧化铝纳米通道的纳米流二极管，具有可调离子整流性能。
ACS Appl Mater Interfaces. 2013 Aug 28;5(16):7931-6. doi: 10.1021/am402004k. Epub 2013 Jul 23.
引用本文的文献
1
Research Progress on Saccharide Molecule Detection Based on Nanopores.基于纳米孔的糖分子检测研究进展。
Sensors (Basel). 2024 Aug 22;24(16):5442. doi: 10.3390/s24165442.
2
The Detection of Trace Metal Contaminants in Organic Products Using Ion Current Rectifying Quartz Nanopipettes.使用离子电流整流石英纳米移液器检测有机产品中的痕量金属污染物
Anal Chem. 2024 Apr 16;96(15):6055-6064. doi: 10.1021/acs.analchem.4c00634. Epub 2024 Apr 3.
3
Mechanistic Study of the Conductance and Enhanced Single-Molecule Detection in a Polymer-Electrolyte Nanopore.聚合物电解质纳米孔中电导及增强单分子检测的机理研究
ACS Nanosci Au. 2023 Jan 10;3(2):172-181. doi: 10.1021/acsnanoscienceau.2c00050. eCollection 2023 Apr 19.
4
Chemically tailoring nanopores for single-molecule sensing and glycomics.化学修饰纳米孔用于单分子传感和糖组学研究。
Anal Bioanal Chem. 2020 Oct;412(25):6639-6654. doi: 10.1007/s00216-020-02717-2. Epub 2020 Jun 1.
5
Surveying silicon nitride nanopores for glycomics and heparin quality assurance.聚糖组学和肝素质量保证用氮化硅纳米孔的检测。
Nat Commun. 2018 Aug 16;9(1):3278. doi: 10.1038/s41467-018-05751-y.
6
Nanofluidic crystals: nanofluidics in a close-packed nanoparticle array.纳米流晶体：紧密堆积的纳米粒子阵列中的纳米流控。
Lab Chip. 2017 Sep 12;17(18):3006-3025. doi: 10.1039/c7lc00588a.
7
Bioinspired integrated nanosystems based on solid-state nanopores: "" transduction of biological, chemical and physical stimuli.基于固态纳米孔的生物启发式集成纳米系统：生物、化学和物理刺激的转导。
Chem Sci. 2017 Feb 1;8(2):890-913. doi: 10.1039/c6sc04255d. Epub 2016 Oct 26.
8
Modulation of Molecular Flux Using a Graphene Nanopore Capacitor.利用石墨烯纳米孔电容器调节分子通量。
J Phys Chem B. 2017 Apr 20;121(15):3724-3733. doi: 10.1021/acs.jpcb.6b10574. Epub 2017 Jan 17.
9
Single-cell intracellular nano-pH probes.单细胞内纳米pH探针
RSC Adv. 2015;5(65):52436-52443. doi: 10.1039/c5ra06721a. Epub 2015 Jun 9.
10
Conductivity-based detection techniques in nanofluidic devices.纳米流体装置中基于电导率的检测技术。
Analyst. 2015 Jul 21;140(14):4779-91. doi: 10.1039/c5an00075k. Epub 2015 May 19.
本文引用的文献
1
Single protein molecule detection by glass nanopores.玻璃纳米孔中单蛋白质分子的检测。
ACS Nano. 2013 May 28;7(5):4129-34. doi: 10.1021/nn4004567. Epub 2013 Apr 22.
2
Copper Sensing with a Prion Protein Modified Nanopipette.用朊病毒蛋白修饰的纳米移液器进行铜传感
RSC Adv. 2012 Jan 1;2(31):11638-11640. doi: 10.1039/C2RA21730A. Epub 2012 Sep 26.
3
Studies of ionic current rectification using polyethyleneimines coated glass nanopipettes.使用涂覆有聚乙烯亚胺的玻璃纳米管研究离子电流整流。
Anal Chem. 2012 Jul 3;84(13):5565-73. doi: 10.1021/ac3004852. Epub 2012 Jun 22.
4
pH gated glucose responsive biomimetic single nanochannels.pH 门控葡萄糖响应仿生单纳米通道。
Chem Commun (Camb). 2012 Apr 4;48(27):3282-4. doi: 10.1039/c2cc17277a. Epub 2012 Jan 25.
5
Electric-field-induced wetting and dewetting in single hydrophobic nanopores.电场诱导单疏水性纳米孔中的润湿和去润湿。
Nat Nanotechnol. 2011 Oct 30;6(12):798-802. doi: 10.1038/nnano.2011.189.
6
Designed glucose-responsive microgels with selective shrinking behavior.设计具有选择性收缩行为的葡萄糖响应性微凝胶。
Langmuir. 2011 Oct 18;27(20):12693-701. doi: 10.1021/la202910k. Epub 2011 Sep 21.
7
Technology behind commercial devices for blood glucose monitoring in diabetes management: a review.商业用血糖仪在糖尿病管理中的技术：综述。
Anal Chim Acta. 2011 Oct 10;703(2):124-36. doi: 10.1016/j.aca.2011.07.024. Epub 2011 Jul 23.
8
Discrimination of neutral oligosaccharides through a nanopore.通过纳米孔区分中性寡糖。
Biochem Biophys Res Commun. 2011 Sep 9;412(4):561-4. doi: 10.1016/j.bbrc.2011.07.121. Epub 2011 Aug 4.
9
Reversible cation response with a protein-modified nanopipette.蛋白质修饰纳米管的可逆阳离子响应。
Anal Chem. 2011 Aug 15;83(16):6121-6. doi: 10.1021/ac201322v. Epub 2011 Jul 22.
10
Controlling molecular transport through nanopores.通过纳米孔控制分子传输。
J R Soc Interface. 2011 Oct 7;8(63):1369-78. doi: 10.1098/rsif.2011.0222. Epub 2011 Jun 29.
Zotero 插件