CoRPS - Center of Research on Psychology in Somatic Diseases, Department of Medical Psychology, Tilburg University, Tilburg, The Netherlands.
Int J Cancer. 2014 Feb 15;134(4):979-87. doi: 10.1002/ijc.28430. Epub 2013 Sep 4.
The literature on the health-related quality of life (HRQOL) after rectal cancer is growing, however, a comparison between patients with nonadvanced disease (NAD), locally advanced rectal cancer (LARC), locally recurrent rectal cancer (LRRC) and a normative population has not been made. Data on the sexual functioning of patient groups is also scarce. We compared (i) the HRQOL of patients with NAD, LARC, or LRRC, with a special focus on sexual functioning and (ii) the HRQOL of the three treatment groups with a normative population. The EORTC QLQ-C30 and QLQ-CR38 were completed by 80 patients with NAD, 292 LARC patients and 67 LRRC patients. The normative population (n = 350) completed the EORTC QLQ-C30 and the Sexual Functioning and Sexual Enjoyment scales of the CR38. LRRC patients reported a lower Physical Function, Social Function, Future Perspective, Sexual Functioning and more Pain compared with LARC and NAD patients. Also, LRRC patients had a worse Body image than NAD patients and a lower Male Sexual Functioning than LARC patients. More than 75% of men and 50% of women were sexually active preoperative, compared with less than 50% and less than 35% postoperative. Male LRRC patients had more problems with erectile or ejaculatory functioning and felt less masculine than NAD or LARC patients. Women did not differ on Lubrication, Dyspareunia and Body Image. About 10% of patients used aids in order to improve erectile functioning (men) or lubrication (women). The treatment groups reported a lower HRQOL and sexual functioning compared with the normative population.
直肠癌患者的健康相关生活质量（HRQOL）文献不断增加，但尚未对非晚期疾病（NAD）、局部晚期直肠癌（LARC）、局部复发性直肠癌（LRRC）患者与普通人群进行比较。关于患者群体性功能的数据也很少。我们比较了（i）NAD、LARC 或 LRRC 患者的 HRQOL，特别关注性功能，以及（ii）三组治疗患者与普通人群的 HRQOL。80 名 NAD 患者、292 名 LARC 患者和 67 名 LRRC 患者完成了 EORTC QLQ-C30 和 QLQ-CR38。普通人群（n=350）完成了 EORTC QLQ-C30 和 CR38 的性功能和性享受量表。LRRC 患者报告的身体功能、社会功能、未来展望、性功能和更多疼痛比 LARC 和 NAD 患者差。此外，LRRC 患者的身体形象比 NAD 患者差，男性性功能比 LARC 患者差。术前超过 75%的男性和 50%的女性有性生活，而术后不到 50%和不到 35%有性生活。男性 LRRC 患者在勃起或射精功能方面存在更多问题，并且比 NAD 或 LARC 患者感觉更不阳刚。女性在润滑、性交疼痛和身体形象方面没有差异。约 10%的患者使用辅助器具以改善勃起功能（男性）或润滑（女性）。与普通人群相比，治疗组报告的 HRQOL 和性功能较低。
