Gao Jingguo
Department of Digestive System, Xingtai People's Hospital, Xingtai, Hebei 054031, P.R. China.
Exp Ther Med. 2013 Jul;6(1):93-96. doi: 10.3892/etm.2013.1101. Epub 2013 May 8.
The aim of this study was to investigate the correlation between anxiety-depression status and cytokines in diarrhea-predominant irritable bowel syndrome (IBS-D). IBS-D patients were divided into an anxiety-depression IBS-D group and a non-anxiety-depression IBS-D group. Patients without IBS, anxiety or depression were selected as the control group. Scoring was performed using the self-rating anxiety scale (SAS) and self-rating depression scale (SDS). Levels of IL-1β and IL-10 in the blood and sigmoid colon mucosa were detected, and the proportions of IL-1β- and IL-10-positive cells in the sigmoid colon mucosa were determined. The results demonstrated that the SDS and SAS scores in the IBS-D group were significantly higher than those in the control group (P<0.05). The levels of IL-1β in the blood and sigmoid colon mucosa and the proportion of IL-1β-positive cells in the sigmoid colon mucosa in the IBS-D group were significantly higher than those in the control group (P<0.05). The levels of IL-10 in the blood and sigmoid colon mucosa and the proportion of IL-10-positive cells in the IBS-D group were significantly lower than those in the control group (P<0.05). The levels of IL-1β in the blood and sigmoid colon mucosa and the proportion of IL-1β-positive cells in the anxiety-depression IBS-D group were significantly higher than those in the non-anxiety-depression IBS-D group, and the levels of IL-10 and the proportion of IL-10-positive cells in the anxiety-depression IBS-D group were significantly lower than those in the non-anxiety-depression IBS-D group (P<0.05). Anxiety-depression status may cause the IL-1β and IL-10 levels in IBS patients to change and result in an imbalance of the proinflammatory and anti-inflammatory cytokines, leading to the occurrence or aggravation of IBS.
本研究旨在探讨腹泻型肠易激综合征（IBS-D）患者焦虑抑郁状态与细胞因子之间的相关性。将IBS-D患者分为焦虑抑郁IBS-D组和非焦虑抑郁IBS-D组。选取无IBS、焦虑或抑郁的患者作为对照组。采用自评焦虑量表（SAS）和自评抑郁量表（SDS）进行评分。检测血液和乙状结肠黏膜中IL-1β和IL-10的水平，并测定乙状结肠黏膜中IL-1β阳性细胞和IL-10阳性细胞的比例。结果显示，IBS-D组的SDS和SAS评分显著高于对照组（P<0.05）。IBS-D组血液和乙状结肠黏膜中IL-1β的水平以及乙状结肠黏膜中IL-1β阳性细胞的比例显著高于对照组（P<0.05）。IBS-D组血液和乙状结肠黏膜中IL-10的水平以及IL-10阳性细胞的比例显著低于对照组（P<0.05）。焦虑抑郁IBS-D组血液和乙状结肠黏膜中IL-1β的水平以及IL-1β阳性细胞的比例显著高于非焦虑抑郁IBS-D组，焦虑抑郁IBS-D组IL-10的水平以及IL-10阳性细胞的比例显著低于非焦虑抑郁IBS-D组（P<0.05）。焦虑抑郁状态可能导致IBS患者IL-1β和IL-10水平发生变化，引起促炎和抗炎细胞因子失衡，导致IBS的发生或加重。
