Isodon nervosus 中的细胞毒 ent-贝壳杉烷二萜。

Cytotoxic ent-kaurane diterpenoids from Isodon nervosus.

机构信息

Department of Phytochemistry, School of Chinese Materia Medica, Guangzhou University of Chinese Medicine, Guangzhou 510006, P. R. China.

出版信息

Chem Biodivers. 2013 Aug;10(8):1487-93. doi: 10.1002/cbdv.201200201.

DOI:10.1002/cbdv.201200201

PMID:23939796

Abstract

Four new ent-kaurane diterpenoids, rabdonervosins G-J (1-4, resp.), were isolated from the leaves and stems of Isodon nervosus. Their structures were elucidated by extensive spectroscopic analyses, including 1D-, 2D-NMR and HR mass spectra. Compound 2 showed potent cytotoxicity against the HepG2 and PC-9/ZD cell lines with IC50 values of 2.36 and 6.07 μM, respectively, and compound 3 exhibited cytotoxicity against the HepG2 and CNE2 cell lines with IC50 values of 8.64 and 9.77 μM, respectively.

摘要

从 Isodon nervosus 的叶和茎中分离得到了 4 个新的 ent-kaurane 二萜类化合物，分别为 rabdonervosins G-J（1-4）。通过广泛的光谱分析，包括 1D-、2D-NMR 和高分辨质谱，确定了它们的结构。化合物 2 对 HepG2 和 PC-9/ZD 细胞系具有较强的细胞毒性，IC50 值分别为 2.36 和 6.07 μM，化合物 3 对 HepG2 和 CNE2 细胞系具有细胞毒性，IC50 值分别为 8.64 和 9.77 μM。