Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Washington State University, Pullman, WA 99164, USA.
Int J Nanomedicine. 2013;8:2809-19. doi: 10.2147/IJN.S44100. Epub 2013 Aug 2.
Bacteria growing as adherent biofilms are difficult to treat and frequently develop resistance to antimicrobial agents. To counter biofilms, various approaches, including prevention of bacterial surface adherence, application of device applicators, and assimilation of antimicrobials in targeted drug delivery machinery, have been utilized. These methods are also combined to achieve synergistic bacterial killing. This review discusses various multimodal technologies, presents general concepts, and describes therapies relying on the principles of electrical energy, ultrasound, photodynamics, and targeted drug delivery for prevention and treatment of biofilms.
当细菌以附着生物膜的形式生长时,它们很难被治疗,并且经常对抗菌药物产生耐药性。为了对抗生物膜,已经采用了各种方法,包括防止细菌表面附着、应用器械敷贴器以及将抗菌药物同化到靶向药物输送机械中。这些方法也被结合起来以实现协同杀菌。本文讨论了各种多模态技术,介绍了一般概念,并描述了依赖电能、超声、光动力和靶向药物输送原理的治疗方法,用于预防和治疗生物膜。