Department of Dermatology, University of Kiel, Germany.
Skin Pharmacol Physiol. 2014;27(1):47-55. doi: 10.1159/000351376. Epub 2013 Aug 14.
Various dietary supplements are claimed to have cutaneous anti-aging properties; however, there are a limited number of research studies supporting these claims. The objective of this research was to study the effectiveness of collagen hydrolysate (CH) composed of specific collagen peptides on skin biophysical parameters related to cutaneous aging. In this double-blind, placebo-controlled trial, 69 women aged 35-55 years were randomized to receive 2.5 g or 5.0 g of CH or placebo once daily for 8 weeks, with 23 subjects being allocated to each treatment group. Skin elasticity, skin moisture, transepidermal water loss and skin roughness were objectively measured before the first oral product application (t0) and after 4 (t1) and 8 weeks (t2) of regular intake. Skin elasticity (primary interest) was also assessed at follow-up 4 weeks after the last intake of CH (t3, 4-week regression phase). At the end of the study, skin elasticity in both CH dosage groups showed a statistically significant improvement in comparison to placebo. After 4 weeks of follow-up treatment, a statistically significantly higher skin elasticity level was determined in elderly women. With regard to skin moisture and skin evaporation, a positive influence of CH treatment could be observed in a subgroup analysis, but data failed to reach a level of statistical significance. No side effects were noted throughout the study.
各种膳食补充剂声称具有皮肤抗衰老特性；然而，仅有数量有限的研究支持这些说法。本研究的目的是研究由特定胶原蛋白肽组成的胶原蛋白水解物 (CH) 对与皮肤衰老相关的皮肤生物物理参数的有效性。在这项双盲、安慰剂对照试验中，69 名年龄在 35-55 岁的女性被随机分为每天服用 2.5 克或 5.0 克 CH 或安慰剂组，每组 23 名受试者。在第一次口服产品应用前（t0）和 4 周（t1）和 8 周（t2）定期摄入后，客观测量皮肤弹性、皮肤水分、经皮水分损失和皮肤粗糙度。在 CH 最后一次摄入后 4 周（t3，4 周回归阶段）还评估了皮肤弹性（主要兴趣）。研究结束时，与安慰剂相比，两个 CH 剂量组的皮肤弹性均显示出统计学上的显著改善。在 4 周的随访治疗后，在老年女性中确定了皮肤弹性水平的统计学显著提高。关于皮肤水分和皮肤蒸发，在亚组分析中可以观察到 CH 治疗的积极影响，但数据未达到统计学意义水平。整个研究过程中均未出现副作用。
