Department of Medicine, Division of Dermatology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
J Dermatolog Treat. 2021 Dec;32(8):991-996. doi: 10.1080/09546634.2020.1725412. Epub 2020 Mar 9.
Topical as well as oral 'collagen' is widely popularized and claimed to possess anti-aging properties for the past several years. Few placebo-controlled trials exist.
: To evaluate the effect of collagen hydrolysate (CH) ingestion for 4 weeks on skin elasticity. : To compare the effects of CH ingestion on skin elasticity between sun-exposed and sun-protected areas.
This study was a prospective, randomized, double-blind placebo-controlled trial comparing the effects of daily intake of 5-g oral CH and placebo in post-menopausal women. Participants were evaluated for skin elasticity, using cutometer at baseline, 2 and 4 weeks after randomization and 4 weeks after discontinuation of study agents.
A total of 36 participants were enrolled. Skin elasticity measured from left and right cheeks in participants receiving CH increased compared to placebo (=.006, .03, respectively). After 4 weeks of discontinuation of study agents (week 8), skin elasticity measured from both left and right cheeks remained different between CH and placebo group (=.01, .004, respectively).
We demonstrated significant improvement of skin elasticity in sun-exposed areas after 4 weeks ingestion of marine CH. The improvement of elasticity remained 4 weeks after discontinuation of study agents. There were no severe adverse effects during the study.
在过去的几年中，局部和口服“胶原蛋白”被广泛推广，并声称具有抗衰老特性。目前仅有少数安慰剂对照试验存在。
评估口服胶原蛋白水解物（CH）4 周对皮肤弹性的影响。比较 CH 口服对暴露于阳光和未暴露于阳光的皮肤弹性的影响。
这是一项前瞻性、随机、双盲、安慰剂对照试验，比较了每日口服 5 克 CH 和安慰剂对绝经后妇女皮肤弹性的影响。在随机分组后 2 周和 4 周以及研究药物停药后 4 周，使用皮肤弹性测量仪评估参与者的皮肤弹性。
共纳入 36 名参与者。与安慰剂相比，接受 CH 治疗的参与者脸颊左侧和右侧的皮肤弹性均增加（=分别为.006 和.03）。在研究药物停药 4 周（第 8 周）后，CH 和安慰剂组脸颊左侧和右侧的皮肤弹性仍存在差异（=分别为.01 和.004）。
我们证明了口服海洋 CH 4 周后可显著改善暴露于阳光的皮肤弹性。在停止使用研究药物 4 周后，弹性仍有改善。研究过程中无严重不良事件发生。
