Division of Rheumatology, Department of Internal Medicine, Korea University College of Medicine , Seoul , Korea.
Immunol Invest. 2013;42(8):749-62. doi: 10.3109/08820139.2013.822394. Epub 2013 Aug 19.
The aim of this study was to assess whether vascular endothelial growth factor (VEGF) polymorphisms are associated with susceptibility to pre-eclampsia.
A meta-analysis was conducted on the associations between the -634 C/G, +936 C/T, -1154 A/G, and -2578 A/C polymorphisms of VEGF and pre-eclampsia.
Ten studies involving 2068 subjects (pre-eclampsia, 950; controls, 1118) were included in the meta-analysis. The meta-analysis revealed an association between pre-eclampsia and the VEGF -634 C allele in overall group (OR = 1.351, 95% CI = 1.105-1.651, p = 0.003) and in European group (OR = 1.427, 95% CI = 1.139-1.787, p = 0.002). The meta-analysis revealed an association between pre-eclampsia and the VEGF -936 T allele in Asians, but not in Europeans (OR = 1.555, 95% CI = 1.232-1.961, p = 1.9 × 10(-5); OR = 1.587, 95% CI = 0.933-2.699, p = 0.088). However, the meta-analysis revealed no association between pre-eclampsia and the VEGF -1154 A/G and 2578 A/C polymorphisms
This meta-analysis suggested that the VEGF -634 C/G polymorphism is associated with susceptibility to pre-eclampsia in Europeans and that the VEGF -634 C/G polymorphism is associated with pre-eclampsia in Asians.
本研究旨在评估血管内皮生长因子（VEGF）多态性是否与子痫前期易感性相关。
对 VEGF-634C/G、+936C/T、-1154A/G 和-2578A/C 多态性与子痫前期的相关性进行了荟萃分析。
纳入了 10 项研究，共 2068 例受试者（子痫前期 950 例，对照组 1118 例）。荟萃分析显示，VEGF-634C 等位基因与子痫前期之间存在关联，总体人群（OR=1.351，95%CI=1.105-1.651，p=0.003）和欧洲人群（OR=1.427，95%CI=1.139-1.787，p=0.002）。荟萃分析显示，VEGF-936T 等位基因与亚洲人群的子痫前期有关，但与欧洲人群无关（OR=1.555，95%CI=1.232-1.961，p=1.9×10(-5)；OR=1.587，95%CI=0.933-2.699，p=0.088）。然而，荟萃分析显示，子痫前期与 VEGF-1154A/G 和 2578A/C 多态性无关。
本荟萃分析提示 VEGF-634C/G 多态性与欧洲人群子痫前期易感性相关，VEGF-634C/G 多态性与亚洲人群子痫前期相关。
