Alsuhaibani Adel H, Carter Keith D, Abràmoff Michael D, Nerad Jeffrey A
Department of Ophthalmology, King Abdulaziz University Hospital, King Saud University, Riyadh, Saudi Arabia.
Saudi J Ophthalmol. 2011 Jan;25(1):61-6. doi: 10.1016/j.sjopt.2010.10.005. Epub 2010 Oct 13.
To study the utility of meibography for the morphology of meibomian glands in normal eyelids and in various eyelid diseases.
A cross-sectional study.
A newly designed transilluminator, fitting both the upper along with lower eyelids, and an infrared camera were used to obtain video clips of the meibomian glands for 60 asymptomatic subjects with normal eyelid margin. Parameters studied included, ocular surface, Schirmer test, and tear breakup time (TBUT). The meibomian glands of patients with meibomian glands' abnormality secondary to infectious, inflammatory, malignant, congenital, or post-radiation therapy disease related etiologies were compared with normal patients. Still pictures were extracted from the video clips to evaluate the meibomian glands for gland dropout and gross morphological changes.
In normal subjects, meibomian glands appeared to be thinner and longer in the upper eye lids than in the lower eye lids. Gland dropout occured with increased age, more in the lower eye lid and in females. Excessive gland drop out (> 75%) was seen in patients with history of trachoma, Stevens Johnson syndrome, severe blepharitis, and post-radiation for orbital tumors. Variable gland drop out was noticed in patients with floppy eyelid syndrome, and blepharitis. In patients with congenital distichiasis, partial or complete gland drop out at the part of the eyelid margins affected by distichiasis was noticed.
The newly designed transilluminator permitted the examination of both upper and lower eye lid meibomian glands with minimal discomfort. Evaluating the anatomical changes involving meibomian glands with meibography may help increase our understanding of the meibomian gland-related diseases, monitor the effects of treatment, and provide helpful information for patient education.
研究睑板腺造影术在正常眼睑及各种眼睑疾病中对睑板腺形态的应用价值。
横断面研究。
使用一种新设计的既能适配上睑又能适配下睑的透照器和一台红外摄像机，为60名睑缘正常的无症状受试者获取睑板腺的视频片段。研究参数包括眼表、泪液分泌试验和泪膜破裂时间（TBUT）。将继发于感染、炎症、恶性、先天性或放疗后疾病相关病因的睑板腺异常患者的睑板腺与正常患者进行比较。从视频片段中提取静态图像，以评估睑板腺的腺体缺失和大体形态变化。
在正常受试者中，上睑的睑板腺似乎比下睑的更细更长。腺体缺失随年龄增长而出现，在下睑和女性中更为常见。有沙眼、史蒂文斯 - 约翰逊综合征、严重睑缘炎病史以及眼眶肿瘤放疗后的患者出现了过多的腺体缺失（>75%）。在眼睑松弛综合征和睑缘炎患者中发现了不同程度的腺体缺失。在先天性双行睫患者中，在受双行睫影响的睑缘部分观察到部分或完全的腺体缺失。
新设计的透照器能在最小程度不适的情况下检查上睑和下睑的睑板腺。通过睑板腺造影术评估涉及睑板腺的解剖学变化可能有助于增加我们对睑板腺相关疾病的理解，监测治疗效果，并为患者教育提供有用信息。
