Center for International Health Research.
J Infect Dis. 2014 Feb 1;209(3):468-72. doi: 10.1093/infdis/jit446. Epub 2013 Aug 20.
Schistosomiasis affects approximately 40 million women of reproductive age and has been linked to elevated levels of circulating endotoxin in nonpregnant individuals. We have evaluated endotoxin levels in maternal, placental, and newborn blood collected from women residing in Leyte, Philippines. Endotoxin levels in both maternal and placental compartments in pregnant women with schistosomiasis were 1.3- and 2.4-fold higher, respectively, than in uninfected women. In addition, higher concentrations of endotoxin in placental blood were associated with premature birth, acute chorioamnionitis, and elevated proinflammatory cytokines. By promoting endotoxemia, schistosomiasis may exert additional, maladaptive influences on pregnancy outcomes.
血吸虫病影响约 4000 万育龄妇女，与非孕妇循环内毒素水平升高有关。我们评估了来自菲律宾莱特岛的妇女的母血、胎盘血和新生儿血中的内毒素水平。患有血吸虫病的孕妇的母血和胎盘血中的内毒素水平分别比未感染者高 1.3 倍和 2.4 倍。此外，胎盘血中更高浓度的内毒素与早产、急性绒毛膜羊膜炎和促炎细胞因子升高有关。通过促进内毒素血症，血吸虫病可能对妊娠结局产生额外的不良影响。
