危地马拉学童补锌计划前后膳食锌摄入量与锌状态生物标志物之间的关联。

Associations among dietary zinc intakes and biomarkers of zinc status before and after a zinc supplementation program in Guatemalan schoolchildren.

作者信息

Bui Vinh Q, Marcinkevage Jessica, Ramakrishnan Usha, Flores-Ayala Rafael C, Ramirez-Zea Manuel, Villalpando Salvador, Martorell Reynaldo, DiGirolamo Ann M, Stein Aryeh D

机构信息

Hubert Department of Global Health, Rollins School of Public Health, Emory University, 1518 Clifton Road, NE, Atlanta, GA 30322, USA.

出版信息

Food Nutr Bull. 2013 Jun;34(2):143-50. doi: 10.1177/156482651303400203.

DOI:10.1177/156482651303400203

PMID:23964387

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4419832/

Abstract

BACKGROUND

The associations among dietary zinc intakes and biomarkers of zinc status are unknown in apparently healthy children at high risk for zinc deficiency.

OBJECTIVE

To assess associations among zinc-related parameters in a sample of Guatemalan school-aged children.

METHODS

We assessed total dietary intakes and biomarkers of zinc status before and after receiving 6 months of zinc supplementation or placebo in 691 Guatemalan schoolchildren aged 6 to 11 years. Most of the children also received zinc-fortified milk from a government program that started shortly after the trial began. We assessed associations between zinc intakes and serum zinc, alkaline phosphatase (ALP), and albumin.

RESULTS

At baseline, the prevalence of serum zinc < 65 microg/dL and dietary zinc intake below Estimated Average Requirements (EAR) (< 4 and < 7 mg/day for children < 9 and > or = 9 years, respectively) were 21.6% and 39.4%, respectively. Pearson correlations between serum zinc concentration and dietary zinc intake, serum ALP, and serum albumin were r = 0.07, 0.15, and 0.07, respectively. At the 6-month follow-up, low serum zinc and low total (diet plus fortified milk) zinc intakes were observed in 1.2% and 0.0% of children in the zinc-supplemented group and 4.0% and 34.1% in the placebo group, respectively. Pearson correlations between serum zinc concentration and total zinc intake, serum ALP, and serum albumin were 0.10, 0.06, and -0.11 in the zinc-supplemented group and -0.04, 0.05, and 0.01 in the placebo group, respectively.

CONCLUSIONS

Zinc intake was inconsistently associated with markers of serum zinc concentration. Zinc fortification or supplementation attenuated the associations.

摘要

背景

在明显健康但有锌缺乏高风险的儿童中，膳食锌摄入量与锌状态生物标志物之间的关联尚不清楚。

目的

评估危地马拉学龄儿童样本中与锌相关参数之间的关联。

方法

我们对691名6至11岁的危地马拉学童进行了评估，在接受6个月的锌补充剂或安慰剂前后，测定了他们的总膳食摄入量和锌状态生物标志物。大多数儿童还从试验开始后不久启动的一项政府项目中获得了强化锌的牛奶。我们评估了锌摄入量与血清锌、碱性磷酸酶（ALP）和白蛋白之间的关联。

结果

在基线时，血清锌<65微克/分升的患病率以及膳食锌摄入量低于估计平均需求量（EAR）（9岁以下儿童分别<4毫克/天和9岁及以上儿童<7毫克/天）的患病率分别为21.6%和39.4%。血清锌浓度与膳食锌摄入量、血清ALP和血清白蛋白之间的Pearson相关性分别为r = 0.07、0.15和0.07。在6个月的随访中，锌补充组中1.2%的儿童和安慰剂组中4.0%的儿童血清锌水平低，锌补充组中0.0%的儿童和安慰剂组中34.1%的儿童总（膳食加强化牛奶）锌摄入量低。锌补充组中血清锌浓度与总锌摄入量、血清ALP和血清白蛋白之间的Pearson相关性分别为0.10、0.06和 -0.11，安慰剂组中分别为 -0.04、0.05和0.01。