Department of Anesthesiology, Division of Critical Care Medicine, Children's Hospital Boston, Harvard Medical School , Boston, Massachusetts 02115, United States.
Nano Lett. 2013 Sep 11;13(9):4410-5. doi: 10.1021/nl402251x. Epub 2013 Aug 21.
The extracellular matrix (ECM) has a quasi-ordered reticular mesostructure with feature sizes on the order of tenths of to a few hundred nanometers. Approaches to preparing biodegradable synthetic scaffolds for engineered tissues that have the critical mesostructure to mimic ECM are few. Here we present a simple and general solvent evaporation-induced self-assembly (EISA) approach to preparing concentrically reticular mesostructured polyol-polyester membranes. The mesostructures were formed by a novel self-assembly process without covalent or electrostatic interactions, which yielded feature sizes matching those of ECM. The mesostructured materials were nonionic, hydrophilic, and water-permeable and could be shaped into arbitrary geometries such as conformally molded tubular sacs and micropatterned meshes. Importantly, the mesostructured polymers were biodegradable and were used as ultrathin temporary substrates for engineering vascular tissue constructs.
细胞外基质（ECM）具有准有序的网状介观结构，特征尺寸为十分之几到几百纳米。用于制备具有模拟 ECM 的关键介观结构的工程组织的可生物降解的合成支架的方法很少。在这里，我们提出了一种简单而通用的溶剂蒸发诱导自组装（EISA）方法来制备同心网状多元醇-聚酯膜。介观结构是通过一种新的自组装过程形成的，没有共价或静电相互作用，其特征尺寸与 ECM 相匹配。介观结构材料是非离子的、亲水的和透水的，可以被塑造成任意形状，如共形模制的管状囊和微图案化的网格。重要的是，介观结构聚合物是可生物降解的，可用作工程血管组织构建的超薄临时基底。
