Authors' Affiliations: Nutritional Epidemiology Branch, Hormonal and Reproductive Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland; and AARP, Washington, District of Columbia.
Cancer Epidemiol Biomarkers Prev. 2013 Nov;22(11):2000-8. doi: 10.1158/1055-9965.EPI-13-0154. Epub 2013 Aug 21.
Physical activity and sedentary behavior may influence ovarian cancer risk, but clear evidence is lacking.
We prospectively investigated the relations of self-reported physical activity and sedentary behavior to ovarian cancer incidence in a cohort of 148,892 U.S. women ages 50-71 years at baseline (1995-1996), who were followed through 2006. Multivariate Cox proportional hazard models were used to estimate relative risks (RR) and 95% confidence intervals (CI). We also conducted analysis by hormone use, body mass index (BMI), and cancer subtype.
We identified 753 incident epithelial ovarian cancers. Overall, neither physical activity nor sedentary behavior at baseline was associated with ovarian cancer risk. Compared with women who never or rarely engaged in vigorous physical activity in the past year, women who reported more than 5 times/week of vigorous physical activity had an RR of 1.05 (95% CI, 0.84-1.32). Women who sat 7+ hours/day had an RR of 1.05 (95% CI, 0.80-1.37) compared with those reporting <3 hours of sitting. The associations were not modified by hormone use or BMI and were similar for both serous and non-serous subtypes.
Physical activity and sedentary behavior in middle and older ages were not associated with ovarian cancer risk.
We found no clear support for a role of physical activity and sedentary behavior in ovarian cancer risk.
体力活动和久坐行为可能会影响卵巢癌的风险，但目前缺乏明确的证据。
我们前瞻性地调查了 148892 名美国女性在基线（1995-1996 年）时的体力活动和久坐行为与卵巢癌发病风险之间的关系，这些女性年龄在 50-71 岁之间，随访至 2006 年。多变量 Cox 比例风险模型用于估计相对风险（RR）和 95%置信区间（CI）。我们还根据激素使用、体重指数（BMI）和癌症亚型进行了分析。
我们确定了 753 例上皮性卵巢癌。总的来说，基线时的体力活动或久坐行为与卵巢癌风险无关。与过去一年中从未或很少进行剧烈体力活动的女性相比，每周进行超过 5 次剧烈体力活动的女性 RR 为 1.05（95%CI，0.84-1.32）。与每天坐 3 小时以下的女性相比，每天坐 7 小时以上的女性 RR 为 1.05（95%CI，0.80-1.37）。这些关联不受激素使用或 BMI 的影响，在浆液性和非浆液性亚型中也相似。
中年和老年时的体力活动和久坐行为与卵巢癌风险无关。
我们没有发现明确的证据表明体力活动和久坐行为与卵巢癌风险有关。
